BPC-157 explained

Gastric Pentadecapeptide BPC-157 (also known as PL 14736, Body Protection Compound 157, or Bepecin) is a fifteen amino acid long oligopeptide that was discovered during research on human gastric juice.[1] The amino acid sequence is as follows: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val.[2]

BPC-157 is stable at room temperature and is resistant to hydrolysis, enzyme digestion, and gastric juice.[3]

Research

Pre-clinical research has indicated that BPC-157 may have cytoprotective, neuroprotective, and anti-inflammatory effects, and may also accelerate tissue and organ healing.[4] [5] [6] [7] [8] [9]

This substance is sometimes used in functional medicine despite not being approved by any drug regulatory agency.[10]

As of 2022, the peptide is banned by the World Anti-Doping Agency under the S0 category of non-exempt substances.[11]

Notes and References

  1. Chang . Chung-Hsun . Tsai . Wen-Chung . Lin . Miao-Sui . Hsu . Ya-Hui . Pang . Jong-Hwei Su . The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration . Journal of Applied Physiology . American Physiological Society . 110 . 3 . 2011 . 8750-7587 . 10.1152/japplphysiol.00945.2010 . 774–780.
  2. Jelovac N, Sikiric P, Rucman R, Petek M, Marovic A, Perovic D, Seiwerth S, Mise S, Turkovic B, Dodig G, Miklic P, Buljat G, Prkacin I . Pentadecapeptide BPC 157 attenuates disturbances induced by neuroleptics: the effect on catalepsy and gastric ulcers in mice and rats . European Journal of Pharmacology . 379 . 1 . 19–31 . August 1999 . 10499368 . 10.1016/S0014-2999(99)00486-0 .
  3. He . Lei . Feng . Donglin . Guo . Hui . Zhou . Yueyuan . Li . Zhaozhao . Zhang . Kuo . Zhang . Wangqian . Wang . Shuning . Wang . Zhaowei . Hao . Qiang . Zhang . Cun . Gao . Yuan . Gu . Jintao . Zhang . Yingqi . Li . Weina . Li . Meng . Pharmacokinetics, distribution, metabolism, and excretion of body-protective compound 157, a potential drug for treating various wounds, in rats and dogs . Frontiers in Pharmacology . Frontiers Media SA . 13 . 2022-12-14 . 1663-9812 . 10.3389/fphar.2022.1026182 . free . 36588717 . 9794587 .
  4. Vukojevic J, Milavić M, Perović D, Ilić S, Čilić AZ, Đuran N, Štrbe S, Zoričić Z, Filipčić I, Brečić P, Seiverth S, Sikirić P . Pentadecapeptide BPC 157 and the central nervous system . Neural Regeneration Research . 17 . 3 . 482–487 . March 2022 . 34380875 . 8504390 . 10.4103/1673-5374.320969 . free .
  5. October 28, 2010 . The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration . Journal of Applied Physiology . 110 . 3 . 774–780 . 10.1152/japplphysiol.00945.2010 . 21030672 . Chang C, Tsai W, Lin M, Hsu Y, Pang JS .
  6. 2003 . Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth . Journal of Orthopaedic Research . 21 . 6 . 976–983 . 10.1016/S0736-0266(03)00110-4 . 14554208 . Staresinic M, Sebecic B, Patrlj L, Jadrijevic S, Suknaic S, Perovic D, Aralica G, Zarkovic N, Borovic S, Srdjak M, Hajdarevic K, Kopljar M, Batelja L, Boban-Blagaic A, Turcic I, Anic T, Seiwerth S, Sikiric P .
  7. Sikiric P, Seiwerth S, Rucman R, Turkovic B, Rokotov DS, Brcic L, Sever M, Klicek R, Radic B, Drmic D, Ilic S, Kolenc D, Vrcic H, Sebecic B . Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract . Current Pharmaceutical Design . 17 . 16 . 1612–32 . 2011 . 21548867 . 10.2174/138161211796196954 .
  8. Sikiric P, Seiwerth S, Brcic L, Blagaic AB, Zoricic I, Sever M, Klicek R, Radic B, Keller N, Sipos K, Jakir A, Udovicic M, Tonkic A, Kokic N, Turkovic B, Mise S, Anic T . Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL 14736, Pliva, Croatia). Full and distended stomach, and vascular response . Inflammopharmacology . 14 . 5–6 . 214–221 . December 2006 . 17186181 . 10.1007/s10787-006-1531-7 . 24132425 .
  9. Cerovecki T, Bojanic I, Brcic L, Radic B, Vukoja I, Seiwerth S, Sikiric P . Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat . Journal of Orthopaedic Research . 28 . 9 . 1155–1161 . September 2010 . 20225319 . 10.1002/jor.21107 . 22085833 .
  10. Sikiric P, Seiwerth S, Rucman R, Kolenc D, Vuletic LB, Drmic D, Grgic T, Strbe S, Zukanovic G, Crvenkovic D, Madzarac G, Rukavina I, Sucic M, Baric M, Starcevic N, Krstonijevic Z, Bencic ML, Filipcic I, Rokotov DS, Vlainic J . Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications . Current Neuropharmacology . 14 . 8 . 857–865 . 2016 . 27138887 . 5333585 . 10.2174/1570159x13666160502153022 .
  11. Web site: 2022 Prohibited List: SUBSTANCES AND METHODS PROHIBITED AT ALL TIMES (IN- AND OUT-OF-COMPETITION) . 21 February 2022 . World Anti-Doping Agency . WADA.

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