BNIPL explained

Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein is a protein that in humans is encoded by the BNIPL gene.^{[1] [2] [3]}

Interactions

BNIPL has been shown to interact with:

• BCL2-like 1,^[4]
• Bcl-2,^[4]
• CDC42,^[5]
• GFER,^[1] and
• Macrophage migration inhibitory factor.

Further reading

• Qin W, Hu J, Guo M, Xu J, Li J, Yao G, Zhou X, Jiang H, Zhang P, Shen L, Wan D, Gu J . BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis . Biochemical and Biophysical Research Communications . 308 . 2 . 379–85 . Aug 2003 . 12901880 . 10.1016/S0006-291X(03)01387-1 .
• Xie L, Qin WX, He XH, Shu HQ, Yao GF, Wan DF, Gu JR . Differential gene expression in human hepatocellular carcinoma Hep3B cells induced by apoptosis-related gene BNIPL-2 . World Journal of Gastroenterology . 10 . 9 . 1286–91 . May 2004 . 15112343 . 10.3748/wjg.v10.i9.1286 . 4622767 . free .
• Xie L, Qin WX, Li JJ, He XH, Shu HQ, Yao GF, Wan DF, Gu JR . cDNA expression array analysis of gene expression in human hepatocarcinoma Hep3B cells induced by BNIPL-1 . Acta Biochimica et Biophysica Sinica . 37 . 9 . 618–24 . Sep 2005 . 16143817 . 10.1111/j.1745-7270.2005.00086.x . free .
• Valencia CA, Cotten SW, Liu R . Cleavage of BNIP-2 and BNIP-XL by caspases . Biochemical and Biophysical Research Communications . 364 . 3 . 495–501 . Dec 2007 . 17961507 . 10.1016/j.bbrc.2007.10.018 .

Notes and References

1. Shen L, Hu J, Lu H, Wu M, Qin W, Wan D, Li YY, Gu J . The apoptosis-associated protein BNIPL interacts with two cell proliferation-related proteins, MIF and GFER . FEBS Letters . 540 . 1–3 . 86–90 . Apr 2003 . 12681488 . 10.1016/S0014-5793(03)00229-1 . free .
2. Zhou YT, Soh UJ, Shang X, Guy GR, Low BC . The BNIP-2 and Cdc42GAP homology/Sec14p-like domain of BNIP-Salpha is a novel apoptosis-inducing sequence . The Journal of Biological Chemistry . 277 . 9 . 7483–92 . Mar 2002 . 11741952 . 10.1074/jbc.M109459200 . free .
3. Web site: Entrez Gene: BNIPL BCL2/adenovirus E1B 19kD interacting protein like.
4. Yasuda M, Han JW, Dionne CA, Boyd JM, Chinnadurai G . BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3 . Cancer Research . 59 . 3 . 533–7 . Feb 1999 . 9973195 .
5. Qin W, Hu J, Guo M, Xu J, Li J, Yao G, Zhou X, Jiang H, Zhang P, Shen L, Wan D, Gu J . BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis . Biochemical and Biophysical Research Communications . 308 . 2 . 379–85 . Aug 2003 . 12901880 . 10.1016/s0006-291x(03)01387-1.