BNIP3L explained

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like is a protein that in humans is encoded by the BNIP3L gene.^{[1] [2] [3]}

Function

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. The protein encoded by this gene is a functional homolog of BNIP3, a proapoptotic protein. This protein may function simultaneously with BNIP3 and may play a role in tumor suppression.^[3]

Interactions

BNIP3L has been shown to interact with STEAP3.^[4]

Further reading

• Chen G, Cizeau J, Vande Velde C, Park JH, Bozek G, Bolton J, Shi L, Dubik D, Greenberg A . Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins. . J. Biol. Chem. . 274 . 1 . 7–10 . 1999 . 9867803 . 10.1074/jbc.274.1.7 . free .
• Ohi N, Tokunaga A, Tsunoda H, Nakano K, Haraguchi K, Oda K, Motoyama N, Nakajima T . A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region. . Cell Death Differ. . 6 . 4 . 314–25 . 1999 . 10381623 . 10.1038/sj.cdd.4400493 . free .
• Imazu T, Shimizu S, Tagami S, Matsushima M, Nakamura Y, Miki T, Okuyama A, Tsujimoto Y . Bcl-2/E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with bcl-2/Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability. . Oncogene . 18 . 32 . 4523–9 . 1999 . 10467396 . 10.1038/sj.onc.1202722 . free .
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 311072 . 10.1101/gr.GR1547R .
• Passer BJ, Nancy-Portebois V, Amzallag N, Prieur S, Cans C, Roborel de Climens A, Fiucci G, Bouvard V, Tuynder M, Susini L, Morchoisne S, Crible V, Lespagnol A, Dausset J, Oren M, Amson R, Telerman A . The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase. . Proc. Natl. Acad. Sci. U.S.A. . 100 . 5 . 2284–9 . 2003 . 12606722 . 151332 . 10.1073/pnas.0530298100 . 2003PNAS..100.2284P . free .
• Aerbajinai W, Giattina M, Lee YT, Raffeld M, Miller JL . The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation. . Blood . 102 . 2 . 712–7 . 2003 . 12663450 . 10.1182/blood-2002-11-3324 . free .
• Sun JL, He XS, Yu YH, Chen ZC . [Expression and structure of BNIP3L in lung cancer] . AI Zheng . 23 . 1 . 8–14 . 2004 . 14720367 .
• Fei P, Wang W, Kim SH, Wang S, Burns TF, Sax JK, Buzzai M, Dicker DT, McKenna WG, Bernhard EJ, El-Deiry WS . Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth. . Cancer Cell . 6 . 6 . 597–609 . 2005 . 15607964 . 10.1016/j.ccr.2004.10.012 . free .
• Stepan H, Leo C, Purz S, Höckel M, Horn LC . Placental localization and expression of the cell death factors BNip3 and Nix in preeclampsia, intrauterine growth retardation and HELLP syndrome. . Eur. J. Obstet. Gynecol. Reprod. Biol. . 122 . 2 . 172–6 . 2006 . 16219518 . 10.1016/j.ejogrb.2005.01.017 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Matsushima M, Fujiwara T, Takahashi E, Minaguchi T, Eguchi Y, Tsujimoto Y, Suzumori K, Nakamura Y . Isolation, mapping, and functional analysis of a novel human cDNA (BNIP3L) encoding a protein homologous to human NIP3 . Genes Chromosomes Cancer . 21 . 3 . 230–5 . May 1998 . 9523198 . 10.1002/(SICI)1098-2264(199803)21:3<230::AID-GCC7>3.0.CO;2-0 . 45529298 .
2. Yasuda M, Han JW, Dionne CA, Boyd JM, Chinnadurai G . BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3 . Cancer Res . 59 . 3 . 533–7 . Feb 1999 . 9973195 .
3. Web site: Entrez Gene: BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like.
4. Passer BJ, Nancy-Portebois V, Amzallag N, Prieur S, Cans C, Roborel de Climens A, Fiucci G, Bouvard V, Tuynder M, Susini L, Morchoisne S, Crible V, Lespagnol A, Dausset J, Oren M, Amson R, Telerman A . The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase . . 100 . 5 . 2284–9 . Mar 2003 . 12606722 . 151332 . 10.1073/pnas.0530298100 . 2003PNAS..100.2284P . free .