BNC1 explained

Zinc finger protein basonuclin-1 is a protein that in humans is encoded by the BNC1 gene.^{[1] [2]}

The protein encoded by this gene is a zinc finger protein present in the basal cell layer of the epidermis and in hair follicles. It is also found in abundance in the germ cells of testis and ovary. This protein is thought to play a regulatory role in keratinocyte proliferation and it may also be a regulator for rRNA transcription. This gene seems to have multiple alternatively spliced transcript variants, but their full-length nature is not known yet. There seems to be evidence of multiple polyadenylation sites for this gene.^[3]

BNC1 or Basonuclin 1 does not interact with PICK1. The suggestion that it does is based on the article that proved that PICK1 interacts with the non-voltage gated sodium channels BNC1 (brain Na⁺ channel 1). Both Basonuclin 1 and brain Na⁺ channel 1 have the same abbreviation BNC1, but they are not similar proteins and PICK1 interacts with the second protein, not the first one.

Further reading

• Tseng H . Basonuclin, a zinc finger protein associated with epithelial expansion and proliferation. . Front. Biosci. . 3 . D985–8 . 1998 . 4 . 9727087 . 10.2741/A338 . free .
• Tseng H, Green H . Association of basonuclin with ability of keratinocytes to multiply and with absence of terminal differentiation. . J. Cell Biol. . 126 . 2 . 495–506 . 1994 . 8034748 . 10.1083/jcb.126.2.495 . 2200026 .
• Teumer J, Tseng H, Green H . The human basonuclin gene. . Gene . 188 . 1 . 1–7 . 1997 . 9099851 . 10.1016/S0378-1119(96)00659-2 . free .
• Yang Z, Gallicano GI, Yu QC, Fuchs E . An unexpected localization of basonuclin in the centrosome, mitochondria, and acrosome of developing spermatids. . J. Cell Biol. . 137 . 3 . 657–69 . 1997 . 9151672 . 10.1083/jcb.137.3.657 . 2139879 .
• Iuchi S, Green H . Nuclear localization of basonuclin in human keratinocytes and the role of phosphorylation. . Proc. Natl. Acad. Sci. U.S.A. . 94 . 15 . 7948–53 . 1997 . 9223293 . 10.1073/pnas.94.15.7948 . 21535 . 1997PNAS...94.7948I . free .
• Mahoney MG, Tang W, Xiang MM . Translocation of the zinc finger protein basonuclin from the mouse germ cell nucleus to the midpiece of the spermatozoon during spermiogenesis. . Biol. Reprod. . 59 . 2 . 388–94 . 1998 . 9687312 . 10.1095/biolreprod59.2.388 . etal. free .
• Iuchi S, Green H . Basonuclin, a zinc finger protein of keratinocytes and reproductive germ cells, binds to the rRNA gene promoter. . Proc. Natl. Acad. Sci. U.S.A. . 96 . 17 . 9628–32 . 1999 . 10449744 . 10.1073/pnas.96.17.9628 . 22260 . 1999PNAS...96.9628I . free .
• Tseng H, Biegel JA, Brown RS . Basonuclin is associated with the ribosomal RNA genes on human keratinocyte mitotic chromosomes. . J. Cell Sci. . 112 Pt 18 . 3039–47 . 2000 . 18 . 10.1242/jcs.112.18.3039 . 10462520 .
• Tang W, Tseng H . A GC-rich sequence within the 5' untranslated region of human basonuclin mRNA inhibits its translation. . Gene . 237 . 1 . 35–44 . 1999 . 10524234 . 10.1016/S0378-1119(99)00299-1 . free .
• Iuchi S, Easley K, Matsuzaki K . Alternative subcellular locations of keratinocyte basonuclin. . Exp. Dermatol. . 9 . 3 . 178–84 . 2000 . 10839715 . 10.1034/j.1600-0625.2000.009003178.x . 5714065 . etal.
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination. . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Brandenberger R, Wei H, Zhang S . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. . Nat. Biotechnol. . 22 . 6 . 707–16 . 2005 . 15146197 . 10.1038/nbt971 . 27764390 . etal.
• Chen L, Willis SN, Wei A . Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. . Mol. Cell . 17 . 3 . 393–403 . 2005 . 15694340 . 10.1016/j.molcel.2004.12.030 . etal. free .
• Vanhoutteghem A, Djian P . Basonuclins 1 and 2, whose genes share a common origin, are proteins with widely different properties and functions. . Proc. Natl. Acad. Sci. U.S.A. . 103 . 33 . 12423–8 . 2006 . 16891417 . 10.1073/pnas.0605086103 . 1567895 . 2006PNAS..10312423V . free .

Notes and References

1. Tseng H, Green H . Basonuclin: a keratinocyte protein with multiple paired zinc fingers . Proc Natl Acad Sci U S A . 89 . 21 . 10311–5 . Dec 1992 . 1332044 . 50328 . 10.1073/pnas.89.21.10311 . 1992PNAS...8910311T . free .
2. Web site: Entrez Gene: BNC1 basonuclin 1.
3. Web site: Entrez Gene: BNC1 basonuclin 1.