Bone morphogenetic protein 8B explained

Bone morphogenetic protein 8B is a protein that in humans is encoded by the BMP8B gene.^{[1] [2] [3]}

The protein encoded by this gene is a member of the TGF-β superfamily. It has close sequence homology to BMP7 and BMP5 and is believed to play a role in bone and cartilage development. It has been shown to be expressed in the hippocampus of murine embryos.

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity.

Further reading

• Gregory SG . The DNA sequence and biological annotation of human chromosome 1 . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . vanc. Barlow KF . McLay KE . 3 . Kaul . R. . Swarbreck . D. . Dunham . A. . Scott . C. E. . Howe . K. L. . Woodfine . K. . 2006Natur.441..315G . free .
• Wen XZ, Akiyama Y, Baylin SB, Yuasa Y . Frequent epigenetic silencing of the bone morphogenetic protein 2 gene through methylation in gastric carcinomas . Oncogene . 25 . 18 . 2666–73 . 2006 . 16314833 . 10.1038/sj.onc.1209297 . free .
• Saito T . Genetic variations in humans associated with differences in the course of hepatitis C . Biochem. Biophys. Res. Commun. . 317 . 2 . 335–41 . 2004 . 15063762 . 10.1016/j.bbrc.2004.03.056 . vanc. Ji G . Shinzawa H . 3 . Okumoto . Kazuo . Hattori . Etsuko . Adachi . Tohru . Takeda . Tadashi . Sugahara . Kazuhiko . Ito . Jun-Itsu .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Ying Y, Qi X, Zhao GQ . Induction of primordial germ cells from murine epiblasts by synergistic action of BMP4 and BMP8B signaling pathways . Proc. Natl. Acad. Sci. U.S.A. . 98 . 14 . 7858–62 . 2001 . 11427739 . 10.1073/pnas.151242798 . 35432 . 2001PNAS...98.7858Y . free .
• Ying Y . Requirement of Bmp8b for the generation of primordial germ cells in the mouse . Mol. Endocrinol. . 14 . 7 . 1053–63 . 2000 . 10894154 . 10.1210/mend.14.7.0479 . vanc. Liu XM . Marble A . 3 . Lawson . KA . Zhao . GQ . free.
• Auffray C . [IMAGE: molecular integration of the analysis of the human genome and its expression] . Comptes Rendus de l'Académie des Sciences, Série III . 318 . 2 . 263–72 . 1995 . 7757816 . vanc. Behar G . Bois F . 3 . Bouchier . C . Da Silva . C . Devignes . MD . Duprat . S . Houlgatte . R . Jumeau . MN .

Notes and References

1. Ozkaynak E, Schnegelsberg PN, Jin DF, Clifford GM, Warren FD, Drier EA, Oppermann H . Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis . J Biol Chem . 267 . 35 . 25220–7 . Jan 1993 . 10.1016/S0021-9258(19)74028-9 . 1460021 . free .
2. DiLeone RJ, King JA, Storm EE, Copeland NG, Jenkins NA, Kingsley DM . The Bmp8 gene is expressed in developing skeletal tissue and maps near the Achondroplasia locus on mouse chromosome 4 . Genomics . 40 . 1 . 196–8 . Jun 1997 . 9070944 . 10.1006/geno.1996.4533 . free .
3. Web site: Entrez Gene: BMP8B bone morphogenetic protein 8b (osteogenic protein 2).