BMP2K explained

BMP-2-inducible protein kinase is an enzyme in humans encoded by the BMP2K gene.^[1]

Function

This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene.

Further reading

• Hoffmann A, Gross G . BMP signaling pathways in cartilage and bone formation . Critical Reviews in Eukaryotic Gene Expression . 11 . 1–3 . 23–45 . 2002 . 11693963 .
• Ueki N, Oda T, Kondo M, Yano K, Noguchi T, Muramatsu M . Selection system for genes encoding nuclear-targeted proteins . Nature Biotechnology . 16 . 13 . 1338–42 . Dec 1998 . 9853615 . 10.1038/4315 . 20001769 .
• Kearns AE, Donohue MM, Sanyal B, Demay MB . Cloning and characterization of a novel protein kinase that impairs osteoblast differentiation in vitro . The Journal of Biological Chemistry . 276 . 45 . 42213–8 . Nov 2001 . 11500515 . 10.1074/jbc.M106163200 . free .
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides . Nature Biotechnology . 21 . 5 . 566–9 . May 2003 . 12665801 . 10.1038/nbt810 . 23783563 .
• Arikawa T, Omura K, Morita I . Regulation of bone morphogenetic protein-2 expression by endogenous prostaglandin E2 in human mesenchymal stem cells . Journal of Cellular Physiology . 200 . 3 . 400–6 . Sep 2004 . 15254968 . 10.1002/jcp.20031 . 28129401 .
• Medici M, van Meurs JB, Rivadeneira F, Zhao H, Arp PP, Hofman A, Pols HA, Uitterlinden AG . BMP-2 gene polymorphisms and osteoporosis: the Rotterdam Study . Journal of Bone and Mineral Research . 21 . 6 . 845–54 . Jun 2006 . 16753015 . 10.1359/jbmr.060306 . 25680897 . free .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . Nov 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Web site: Entrez Gene: BMP2K BMP2 inducible kinase.