BLOC1S1 explained

Biogenesis of lysosome-related organelles complex 1 subunit 1 is a protein that in humans is encoded by the BLOC1S1 gene.^{[1] [2] [3]}

BLOC1S1 is a component of the ubiquitously expressed BLOC1 multisubunit protein complex. BLOC1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules (Starcevic and Dell'Angelica, 2004).[supplied by OMIM]

Interactions

BLOC1S1 has been shown to interact with BLOC1S2, SNAPAP^[2] and PLDN.^[2]

Further reading

• Watanabe TK, Fujiwara T, Shinomiya H . Molecular cloning of a novel human cDNA, RT14, containing a putative ORF highly conserved between human, fruit fly, and nematode. . DNA Res. . 2 . 5 . 235–7 . 1997 . 8770567 . 10.1093/dnares/2.5.235 . etal. free .
• Ogryzko VV, Kotani T, Zhang X . Histone-like TAFs within the PCAF histone acetylase complex. . Cell . 94 . 1 . 35–44 . 1998 . 9674425 . 10.1016/S0092-8674(00)81219-2 . 18942972 . etal. free .
• McMahon SB, Wood MA, Cole MD . The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc. . Mol. Cell. Biol. . 20 . 2 . 556–62 . 2000 . 10611234 . 10.1128/MCB.20.2.556-562.2000 . 85131 .
• Kurooka H, Honjo T . Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5. . J. Biol. Chem. . 275 . 22 . 17211–20 . 2000 . 10747963 . 10.1074/jbc.M000909200 . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Mishra SK, Mazumdar A, Vadlamudi RK . MICoA, a novel metastasis-associated protein 1 (MTA1) interacting protein coactivator, regulates estrogen receptor-alpha transactivation functions. . J. Biol. Chem. . 278 . 21 . 19209–19 . 2003 . 12639951 . 10.1074/jbc.M301968200 . etal. free.
• Lehner B, Semple JI, Brown SE . Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. . Genomics . 83 . 1 . 153–67 . 2004 . 14667819 . 10.1016/S0888-7543(03)00235-0 . etal.

Notes and References

1. Inoue M, Isomura M, Ikegawa S, Fujiwara T, Shin S, Moriya H, Nakamura Y . Isolation and characterization of a human cDNA clone (GCN5L1) homologous to GCN5, a yeast transcription activator . Cytogenet Cell Genet . 73 . 1–2 . 134–6 . Jul 1996 . 8646881 . 10.1159/000134324 .
2. Starcevic M, Dell'Angelica EC . Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1) . J Biol Chem . 279 . 27 . 28393–401 . Jun 2004 . 15102850 . 10.1074/jbc.M402513200 . free .
3. Web site: Entrez Gene: BLOC1S1 biogenesis of lysosome-related organelles complex-1, subunit 1.