BIRC7 explained

Baculoviral IAP repeat-containing protein 7 is a protein that in humans is encoded by the BIRC7 gene.^{[1] [2] [3]}

The protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide.^[3] In melanoma, BIRC7 gene expression is regulated by the Microphthalmia-associated transcription factor.^{[4] [5]}

Further reading

• Bavykin AS . Double siRNA-targeting of cIAP2 and LIVIN results in synergetic sensitization of HCT-116 cells to oxaliplatin treatment . OncoTargets Ther . 6 . 1333–40 . 2013 . 3789649 . 10.2147/OTT.S44893 . vanc. Korotaeva AA . Poyarkov SV . 3 . Syrtsev AV . Tjulandin SA . Karpukhin AV . 24098083 . 6 . free .
• Vucic D . ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas . Curr. Biol. . 10 . 21 . 1359–66 . 2001 . 11084335 . 10.1016/S0960-9822(00)00781-8 . vanc. Stennicke HR . Pisabarro MT . 3 . Salvesen . Guy S. . Dixit . Vishva M. . 10381671 . free.
• Ashhab Y . Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern . FEBS Lett. . 495 . 1–2 . 56–60 . 2001 . 11322947 . 10.1016/S0014-5793(01)02366-3 . vanc. Alian A . Polliack A . 3 . Panet . A . Ben Yehuda . D . 46380628 .
• Deloukas P . The DNA sequence and comparative analysis of human chromosome 20 . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . vanc. Matthews LH . Ashurst J . 3 . Burton . J. . Gilbert . J. G. R. . Jones . M. . Stavrides . G. . Almeida . J. P. . Babbage . A. K. . 2001Natur.414..865D . free .
• Vucic D . SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP) . J. Biol. Chem. . 277 . 14 . 12275–9 . 2002 . 11801603 . 10.1074/jbc.M112045200 . vanc. Deshayes K . Ackerly H . 3 . Pisabarro . MT . Kadkhodayan . S . Fairbrother . WJ . Dixit . VM . free .
• Sanna MG . IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition . Mol. Cell. Biol. . 22 . 6 . 1754–66 . 2002 . 11865055 . 10.1128/MCB.22.6.1754-1766.2002 . 135597 . vanc. da Silva Correia J . Ducrey O . 3 . Lee . J. . Nomoto . K. . Schrantz . N. . Deveraux . Q. L. . Ulevitch . R. J. .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Gazzaniga P . Expression and prognostic significance of LIVIN, SURVIVIN and other apoptosis-related genes in the progression of superficial bladder cancer . Ann. Oncol. . 14 . 1 . 85–90 . 2003 . 12488298 . 10.1093/annonc/mdg002 . vanc. Gradilone A . Giuliani L . 3 . Gandini . O . Silvestri . I . Nofroni . I . Saccani . G . Frati . L . Aglianò . AM . free .
• Clark HF . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 . vanc. Gurney AL . Abaya E . 3 . Baker . K . Baldwin . D . Brush . J . Chen . J . Chow . B . Chui . C .
• Crnkovic-Mertens I, Hoppe-Seyler F, Butz K . Induction of apoptosis in tumor cells by siRNA-mediated silencing of the livin/ML-IAP/KIAP gene . Oncogene . 22 . 51 . 8330–6 . 2004 . 14614456 . 10.1038/sj.onc.1206973 . 21897515 .
• Andersen MH, Reker S, Becker JC, ((thor Straten P)) . The melanoma inhibitor of apoptosis protein: a target for spontaneous cytotoxic T cell responses . J. Invest. Dermatol. . 122 . 2 . 392–9 . 2004 . 15009721 . 10.1046/j.0022-202X.2004.22242.x . free .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Tanabe H . Expression of survivin mRNA and livin mRNA in non-small-cell lung cancer . Lung Cancer . 46 . 3 . 299–304 . 2005 . 15541814 . 10.1016/j.lungcan.2004.05.002 . vanc. Yagihashi A . Tsuji N . 3 . Shijubo . Y . Abe . S . Watanabe . N .
• Yagihashi A . Detection of autoantibodies to survivin and livin in sera from patients with breast cancer . Clin. Chim. Acta . 362 . 1–2 . 125–30 . 2006 . 16026775 . 10.1016/j.cccn.2005.06.009 . vanc. Ohmura T . Asanuma K . 3 . Kobayashi . D . Tsuji . N . Torigoe . T . Sato . N . Hirata . K . Watanabe . N .
• Crnković-Mertens I, Semzow J, Hoppe-Seyler F, Butz K . Isoform-specific silencing of the Livin gene by RNA interference defines Livin beta as key mediator of apoptosis inhibition in HeLa cells . J. Mol. Med. . 84 . 3 . 232–40 . 2006 . 16437214 . 10.1007/s00109-005-0021-5 . 28468027 .
• Ma L . Livin promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway . Cell Death Differ. . 13 . 12 . 2079–88 . 2007 . 16729033 . 10.1038/sj.cdd.4401959 . vanc. Huang Y . Song Z . 3 . Feng . S . Tian . X . Du . W . Qiu . X . Heese . K . Wu . M . free .
• Yan H . Proteolytic cleavage of Livin (ML-IAP) in apoptotic melanoma cells potentially mediated by a non-canonical caspase . J. Dermatol. Sci. . 43 . 3 . 189–200 . 2006 . 16806840 . 10.1016/j.jdermsci.2006.05.007 . 2292408 . vanc. Brouha B . Liu T . 3 . Raj . Deepak . Biddle . Diana . Lee . Ray . Grossman . Douglas .
• Wu H . Expression of BIRC7 protein and mRNA in non-Hodgkin's lymphoma . Leuk. Lymphoma . 47 . 6 . 1110–6 . 2007 . 16840203 . 10.1080/10428190500472271 . vanc. Ma Y . Zhu Y . 3 . Shen . Yan . Gu . Congming . Ye . Ziyin . Lin . Hanliang . 24671993 .
• Crnković-Mertens I . The anti-apoptotic livin gene is an important determinant for the apoptotic resistance of non-small cell lung cancer cells . Lung Cancer . 54 . 2 . 135–42 . 2007 . 16965834 . 10.1016/j.lungcan.2006.07.018 . vanc. Muley T . Meister M . 3 . Hartenstein . B . Semzow . J . Butz . K . Hoppeseyler . F .

Notes and References

1. Kasof GM, Gomes BC . Livin, a novel inhibitor of apoptosis protein family member . J Biol Chem . 276 . 5 . 3238–46 . May 2001 . 11024045 . 10.1074/jbc.M003670200 . free .
2. Lin JH, Deng G, Huang Q, Morser J . KIAP, a novel member of the inhibitor of apoptosis protein family . Biochem Biophys Res Commun . 279 . 3 . 820–31 . Feb 2001 . 11162435 . 10.1006/bbrc.2000.4027 .
3. Web site: Entrez Gene: BIRC7 baculoviral IAP repeat-containing 7 (livin).
4. Dynek JN . Microphthalmia-associated transcription factor is a critical transcriptional regulator of melanoma inhibitor of apoptosis in melanomas . Cancer Res. . 68 . 9 . 3124–32 . 2008 . 18451137 . 10.1158/0008-5472.CAN-07-6622 . vanc. Chan SM . Liu J . 3 . Zha . J. . Fairbrother . W. J. . Vucic . D. . free .
5. Hoek KS . Novel MITF targets identified using a two-step DNA microarray strategy . Pigment Cell Melanoma Res. . 21 . 6 . 665–76 . 2008 . 19067971. 10.1111/j.1755-148X.2008.00505.x . vanc. Schlegel NC . Eichhoff OM . 3 . Widmer . Daniel S. . Praetorius . Christian . Einarsson . Steingrimur O. . Valgeirsdottir . Sigridur . Bergsteinsdottir . Kristin . Schepsky . Alexander . 24698373 . free .