Baculoviral IAP repeat-containing protein 2 explained

Baculoviral IAP repeat-containing protein 2 (also known as cIAP1) is a protein that in humans is encoded by the BIRC2 gene.^{[1] [2]}

Function

cIAP1 is a member of the Inhibitor of Apoptosis family that inhibit apoptosis by interfering with the activation of caspases.

Interactions

BIRC2 has been shown to interact with:

• CASP9,^[3]
• DIABLO,^[4]
• GSPT1,
• HSP90B1,^[5]
• HTRA2,^{[6] [7]}
• RIPK1,^[8]
• RIPK2^{[9] [10]}
• TNFSF14,^[11]
• TRAF1,^{[12] [13] [14]}
• TRAF2,^{[12] [13] [14] [15] [16] [17]} and
• UBC.^{[5] [8] [18]}

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Uren AG, Pakusch M, Hawkins CJ, Puls KL, Vaux DL . Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors. . Proc. Natl. Acad. Sci. U.S.A. . 93 . 10 . 4974–8 . 1996 . 8643514 . 39390 . 10.1073/pnas.93.10.4974 . 1996PNAS...93.4974U . free .
• Rajcan-Separovic E, Liston P, Lefebvre C, Korneluk RG . Assignment of human inhibitor of apoptosis protein (IAP) genes xiap, hiap-1, and hiap-2 to chromosomes Xq25 and 11q22-q23 by fluorescence in situ hybridization. . Genomics . 37 . 3 . 404–6 . 1997 . 8938457 . 10.1006/geno.1996.0579 .
• Shu HB, Takeuchi M, Goeddel DV . The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex. . Proc. Natl. Acad. Sci. U.S.A. . 93 . 24 . 13973–8 . 1997 . 8943045 . 19479 . 10.1073/pnas.93.24.13973 . 1996PNAS...9313973S . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC . The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. . EMBO J. . 16 . 23 . 6914–25 . 1998 . 9384571 . 1170295 . 10.1093/emboj/16.23.6914 .
• Deveraux QL, Roy N, Stennicke HR, Van Arsdale T, Zhou Q, Srinivasula SM, Alnemri ES, Salvesen GS, Reed JC . IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. . EMBO J. . 17 . 8 . 2215–23 . 1998 . 9545235 . 1170566 . 10.1093/emboj/17.8.2215 .
• McCarthy JV, Ni J, Dixit VM . RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase. . J. Biol. Chem. . 273 . 27 . 16968–75 . 1998 . 9642260 . 10.1074/jbc.273.27.16968 . free .
• Young SS, Liston P, Xuan JY, McRoberts C, Lefebvre CA, Korneluk RG . Genomic organization and physical map of the human inhibitors of apoptosis: HIAP1 and HIAP2. . Mamm. Genome . 10 . 1 . 44–8 . 1999 . 9892732 . 10.1007/s003359900940 . 7052915 .
• Hinds MG, Norton RS, Vaux DL, Day CL . Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat. . Nat. Struct. Biol. . 6 . 7 . 648–51 . 1999 . 10404221 . 10.1038/10701 . 3194182 .
• Verhagen AM, Ekert PG, Pakusch M, Silke J, Connolly LM, Reid GE, Moritz RL, Simpson RJ, Vaux DL . Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. . Cell . 102 . 1 . 43–53 . 2000 . 10929712 . 10.1016/S0092-8674(00)00009-X . 3192775 . free .
• Vucic D, Stennicke HR, Pisabarro MT, Salvesen GS, Dixit VM . ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas. . Curr. Biol. . 10 . 21 . 1359–66 . 2001 . 11084335 . 10.1016/S0960-9822(00)00781-8 . 10381671 . free .
• Werneburg BG, Zoog SJ, Dang TT, Kehry MR, Crute JJ . Molecular characterization of CD40 signaling intermediates. . J. Biol. Chem. . 276 . 46 . 43334–42 . 2001 . 11562359 . 10.1074/jbc.M104994200 . free .
• Suzuki Y, Imai Y, Nakayama H, Takahashi K, Takio K, Takahashi R . A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. . Mol. Cell . 8 . 3 . 613–21 . 2001 . 11583623 . 10.1016/S1097-2765(01)00341-0 . free .
• Verhagen AM, Silke J, Ekert PG, Pakusch M, Kaufmann H, Connolly LM, Day CL, Tikoo A, Burke R, Wrobel C, Moritz RL, Simpson RJ, Vaux DL . HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins. . J. Biol. Chem. . 277 . 1 . 445–54 . 2002 . 11604410 . 10.1074/jbc.M109891200 . free .
• Mellström B, Ceña V, Lamas M, Perales C, Gonzalez C, Naranjo JR . Gas1 is induced during and participates in excitotoxic neuronal death. . Mol. Cell. Neurosci. . 19 . 3 . 417–29 . 2002 . 11906213 . 10.1006/mcne.2001.1092 . 31105269 .
• Li X, Yang Y, Ashwell JD . TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. . Nature . 416 . 6878 . 345–7 . 2002 . 11907583 . 10.1038/416345a . 2002Natur.416..345L . 4325926 .
• Imoto I, Tsuda H, Hirasawa A, Miura M, Sakamoto M, Hirohashi S, Inazawa J . Expression of cIAP1, a target for 11q22 amplification, correlates with resistance of cervical cancers to radiotherapy. . Cancer Res. . 62 . 17 . 4860–6 . 2002 . 12208731 .

Notes and References

1. Liston P, Roy N, Tamai K, Lefebvre C, Baird S, Cherton-Horvat G, Farahani R, McLean M, Ikeda JE, MacKenzie A, Korneluk RG . Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes . Nature . 379 . 6563 . 349–53 . February 1996 . 8552191 . 10.1038/379349a0 . 1996Natur.379..349L . 4305853 .
2. Rothe M, Pan MG, Henzel WJ, Ayres TM, Goeddel DV . The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins . Cell . 83 . 7 . 1243–52 . February 1996 . 8548810 . 10.1016/0092-8674(95)90149-3 . free .
3. Deveraux QL, Roy N, Stennicke HR, Van Arsdale T, Zhou Q, Srinivasula SM, Alnemri ES, Salvesen GS, Reed JC . IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases . EMBO J. . 17 . 8 . 2215–23 . 1998 . 9545235 . 1170566 . 10.1093/emboj/17.8.2215 .
4. Verhagen AM, Ekert PG, Pakusch M, Silke J, Connolly LM, Reid GE, Moritz RL, Simpson RJ, Vaux DL . Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins . Cell . 102 . 1 . 43–53 . 2000 . 10929712 . 10.1016/S0092-8674(00)00009-X . 3192775 . free .
5. Didelot C, Lanneau D, Brunet M, Bouchot A, Cartier J, Jacquel A, Ducoroy P, Cathelin S, Decologne N, Chiosis G, Dubrez-Daloz L, Solary E, Garrido C . Interaction of heat-shock protein 90 beta isoform (HSP90 beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation . Cell Death Differ. . 15 . 5 . 859–66 . 2008 . 18239673 . 10.1038/cdd.2008.5 . free .
6. Hegde R, Srinivasula SM, Datta P, Madesh M, Wassell R, Zhang Z, Cheong N, Nejmeh J, Fernandes-Alnemri T, Hoshino S, Alnemri ES . The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein . J. Biol. Chem. . 278 . 40 . 38699–706 . 2003 . 12865429 . 10.1074/jbc.M303179200 . free .
7. Verhagen AM, Silke J, Ekert PG, Pakusch M, Kaufmann H, Connolly LM, Day CL, Tikoo A, Burke R, Wrobel C, Moritz RL, Simpson RJ, Vaux DL . HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins . J. Biol. Chem. . 277 . 1 . 445–54 . 2002 . 11604410 . 10.1074/jbc.M109891200 . free .
8. Bertrand MJ, Milutinovic S, Dickson KM, Ho WC, Boudreault A, Durkin J, Gillard JW, Jaquith JB, Morris SJ, Barker PA . cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination . Mol. Cell . 30 . 6 . 689–700 . 2008 . 18570872 . 10.1016/j.molcel.2008.05.014 . free .
9. McCarthy JV, Ni J, Dixit VM . RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase . J. Biol. Chem. . 273 . 27 . 16968–75 . 1998 . 9642260 . 10.1074/jbc.273.27.16968 . free .
10. Thome M, Hofmann K, Burns K, Martinon F, Bodmer JL, Mattmann C, Tschopp J . Identification of CARDIAK, a RIP-like kinase that associates with caspase-1 . Curr. Biol. . 8 . 15 . 885–8 . 1998 . 9705938 . 10.1016/S0960-9822(07)00352-1 . 1235278 . free .
11. Kuai J, Nickbarg E, Wooters J, Qiu Y, Wang J, Lin LL . Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis . J. Biol. Chem. . 278 . 16 . 14363–9 . 2003 . 12571250 . 10.1074/jbc.M208672200 . free .
12. Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC . The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases . EMBO J. . 16 . 23 . 6914–25 . 1997 . 9384571 . 1170295 . 10.1093/emboj/16.23.6914 .
13. Shu HB, Takeuchi M, Goeddel DV . The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex . Proc. Natl. Acad. Sci. U.S.A. . 93 . 24 . 13973–8 . 1996 . 8943045 . 19479 . 10.1073/pnas.93.24.13973 . 1996PNAS...9313973S . free .
14. Li X, Yang Y, Ashwell JD . TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2 . Nature . 416 . 6878 . 345–7 . 2002 . 11907583 . 10.1038/416345a . 2002Natur.416..345L . 4325926 .
15. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
16. Uren AG, Pakusch M, Hawkins CJ, Puls KL, Vaux DL . Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors . Proc. Natl. Acad. Sci. U.S.A. . 93 . 10 . 4974–8 . 1996 . 8643514 . 39390 . 10.1073/pnas.93.10.4974 . 1996PNAS...93.4974U . free .
17. Yoneda T, Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T, Sato N, Gomi F, Morihara T, Mori Y, Miyoshi K, Hitomi J, Ugawa S, Yamada S, Okabe M, Tohyama M . Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein . J. Biol. Chem. . 275 . 15 . 11114–20 . 2000 . 10753917 . 10.1074/jbc.275.15.11114 . free.
18. Sekine K, Takubo K, Kikuchi R, Nishimoto M, Kitagawa M, Abe F, Nishikawa K, Tsuruo T, Naito M . Small molecules destabilize cIAP1 by activating auto-ubiquitylation . J. Biol. Chem. . 283 . 14 . 8961–8 . 2008 . 18230607 . 10.1074/jbc.M709525200 . free .