Biobase (company) explained

BIOBASE GmbH
Foundation:	Wolfenbuettel, Germany (1997)
Key People:	Michael Tysiak (CEO & CFO), Dr. Frank Schacherer (CTO)
Industry:	Bioinformatics databases
Products:	BIOBASE Knowledge Library, TRANSFAC, Proteome databases, ExPlain,
Services:	Knowledge process outsourcing, custom curation, ExPlain analysis
Num Employees:	~150 (2008)

BIOBASE is an international bioinformatics company headquartered in Wolfenbüttel, Germany. The company focuses on the generation, maintenance, and licensing of databases in the field of molecular biology, and their related software platforms.

History

The company was founded in 1997 as a spin-off from the German Research Centre for Biotechnology (GBF), Braunschweig, Germany, known today as the Helmholtz Research Centre for Infection Research. *The founders were scientists of the GBF Research Group Bioinformatics, headed at that time by Edgar Wingender. The company is now managed by Michael Tysiak (CEO/CFO) and Frank Schacherer (COO).

The company's original product was the TRANSFAC database, a platform for the description and analysis of gene regulatory events and networks. This was subsequently complemented by a number of smaller databases relevant to aspects of gene regulation, and by an early signaling pathway database (TRANSPATH). TRANSPATH constituted the earliest signaling pathway database, alongside the Cell Signaling Network Database (CSNDB) curated by T. Takai at the National Institute of Health Sciences (NIHS) in Tokyo.

By end of 1999, BIOBASE acquired venture capital from the IMH funds, now managed by Triginta Capital, by the MBG (Hannover; until 2007) and the tbg. In 2002, Intec W&G, Tokyo, Japan, invested in the company and remained a shareholder until 2005.In early 2005, the company acquired the databases produced by Incyte, Wilmington, Delaware, USA, which were operated at the time by Incyte's subsidiary, Proteome Inc in Beverly, MA. The early flagship of Proteome was the Yeast Proteome Database (YPD), which was complemented by a number of similar databases. Their latest achievement before the acquisition was the Human Proteome Survey Database (HumanPSD).

BIOBASE with all subsidiaries was acquired by QIAGEN GmbH on April 2, 2014.

Subsidiaries

BIOBASE GmbH has three fully owned daughter companies: BIOBASE Corporation in Beverly/Massachusetts, USA (since 2005),^[1] BIOBASE Databases India Pvt Ltd. in Bangalore, India (since 2006),^[2] and BIOBASE Japan K.K. in Yokohama, Japan (since 2007).^[3]

Products and services

The company's databases provide manually curated content, collected and structured from peer-reviewed scientific primary publications.

The BIOBASE Knowledge Library (BKL) is an integrated database comprising the following modules:^[4]

• TRANSFAC: Eukaryotic transcription factors, their genomic DNA-binding sites and DNA-binding profiles ^[5]
• TRANSCompel: Transcription regulating composite elements
• TRANSPro: Promoter sequences from a number of selected eukaryotic species
• PathoDB: Pathologically relevant mutations in transcription factors and their binding sites
• TRANSPATH: Signal transduction and metabolic pathways in mammalian species ^[6]
• YPD: The complete yeast proteome (protein reports for all known Saccharomyces cerevisiae proteins) ^[7]
• PombePD, MycopathPD: Proteomes of Schizosaccharomyces pombe and of pathological fungi ^[7]
• WormPD: The proteome of Caenorhabditis elegans ^[7]
• HumanPSD: The proteomes of human, mouse and rat [8]
• GPCR-PD: G-protein coupled receptor reports ^[8]

In addition, BIOBASE has developed the ExPlain system for the biological interpretation of gene expression and proteomics data by integrated functional, promoter and pathway analysis.

The "Gene Regulation Portal" offers a number of earlier revisions of company products free of charge to users from non-profit organizations.

A number of third-party products are also distributed by BIOBASE:

• S/MARt DB: Scaffold/matrix attached regions (HZI Braunschweig) ^[9]
• BRENDA: The BRaunschweig ENzyme DAtabase (Technical University Braunschweig Enzymeta) ^{[10] [11]}
• HGMD: The Human Gene Mutation Database (Cardiff University) ^[12]
• CI: Cell Illustrator for pathway simulations (Tokyo University/GNI, Tokyo) ^{[13] [14]}

In addition to these products, BIOBASE offers Knowledge process outsourcing (KPO) services. These may comprise the development and population of customized databases with specific contents, or systematic analyses of gene expression data.

Scientific projects/research

BIOBASE is a member of the following publicly funded research consortia, the first two of them being coordinated by BIOBASE (Alexander Kel):^[15]

• Net2Drug: Integrated Labwork, Bio- and Cheminformatics technology for fighting breast cancer (9 partners; funded under EU6) https://web.archive.org/web/20110111035825/http://www.biobase.de/pages/index.php?id=437 ^[16]
• Sysco: Combined experimental, bioinformatics and simulation approaches to analyze intracellular parasitism (8 partners; funded under EU6) ^{[17] [18]}
• TRANSISTOR: Bioinformatics modeling of plant regulatory circuits (7 partners; Marie-Curie Project funded under EU6) ^[19]
• Valapodyn: Dynamic modeling of data on brain pathologies (7 partners; funded under EU6)
• Eurodia: Potential targets for prevention and treatment of dysfunctional insulin secretion in type 2 diabetes (20 partners; funded under EU6)
• Gen2Phen: Unified genotype-phenotype database (19 partners; funded under EU7) ^[20]
• LipidomicNet: Identification of targets for and biomarkers of energy overload diseases through lipid protein interactions (21 partners; funded under EU7);
• GlobCell: Global scale analysis and prediction of human cellular behaviour in a complex environment (4 partners; funded by Eurotrans-Bio, ETB).
• TCellTalk: (3 partners; funded by German Ministry of Research in the Forsys partnering program)

In addition, BIOBASE has entered research partnerships with

• University Medicine of Georg August University of Göttingen, Göttingen, Germany (E. Wingender);
• University of Tokyo, Tokyo, Japan (S. Miyano);
• Windber Research Institute & Strategic Medicine, Inc, Windber/PA, USA (M. Liebman);
• Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany;^[21]
• Lawrence Berkeley National Laboratory, Berkeley/CA, USA (I. Dubchak)^[22]

See also

• Gene expression
• Bioinformatics
• Bioinformatics companies

External links

• Official website
• Gene Regulation Portal
• Helmholtz Research Centre for Infection Research Official website

Notes and References

1. http://findarticles.com/p/articles/mi_m0EIN/is_2005_Jan_18/ai_n8699647 BIOBASE acquires Proteome from Incyte
2. http://biospectrumindia.ciol.com/content/news/40611091.asp BIOBASE opens Bangalore office
3. Web site: BIOBASE opens Yokohama office . . 2017-06-30 . 2013-02-01 . https://archive.today/20130201084133/http://www.reuters.com/article/pressRelease/idUS242892+24-Jan-2008+BW20080124 . dead .
4. Wingender . E . Crass . T . Hogan . JD . Kel . AE . Kel-Margoulis . OV . Potapov . AP . Integrative content-driven concepts for bioinformatics "beyond the cell" . . 32 . 1 . 169–80 . 2007 . 17426389 . 10.1007/s12038-007-0015-2. 16360290 .
5. Matys . V . Kel-Margoulis . OV . Fricke . E . Liebich . I . Land . S . Barre-Dirrie . A . Reuter . I . Chekmenev . D . Krull . M . Hornischer . K . Voss . N . Stegmaier . P . Lewicki-Potapov . B . Saxel . H . Kel . A. E. . Wingender . E . TRANSFAC and its module TRANSCompel: transcriptional gene regulation in eukaryotes . . 34 . Database issue . D108–10 . 2006 . 16381825 . 1347505 . 10.1093/nar/gkj143 . 8 .
6. Krull . M . Pistor . S . Voss . N . Kel . A . Reuter . I . Kronenberg . D . Michael . H . Schwarzer . K . Potapov . A . Choi . C . Kel-Margoulis . O . Wingender . E . TRANSPATH: an information resource for storing and visualizing signaling pathways and their pathological aberrations . Nucleic Acids Research . 34 . Database issue . D546–51 . 2006 . 16381929 . 1347469 . 10.1093/nar/gkj107 . 8 .
7. Costanzo . MC . Crawford . ME . Hirschman . JE . Kranz . JE . Olsen . P . Robertson . LS . Skrzypek . MS . Braun . BR . Hopkins . KL . Kondu . P . Lengieza . C . Lew-Smith . J. E. . Tillberg . M . Garrels . J. I. . YPD, PombePD and WormPD: model organism volumes of the BioKnowledge library, an integrated resource for protein information . Nucleic Acids Research . 29 . 1 . 75–9 . 2001 . 11125054 . 29810 . 10.1093/nar/29.1.75. 8 .
8. Hodges . PE . Carrico . PM . Hogan . JD . O'Neill . KE . Owen . JJ . Mangan . M . Davis . BP . Brooks . JE . Garrels . JI . Annotating the human proteome: the Human Proteome Survey Database (HumanPSD) and an in-depth target database for G protein-coupled receptors (GPCR-PD) from Incyte Genomics . Nucleic Acids Research . 30 . 1 . 137–41 . 2002 . 11752275 . 99168 . 10.1093/nar/30.1.137 .
9. Liebich . I . Bode . J . Frisch . M . Wingender . E . S/MARt DB: a database on scaffold/matrix attached regions . Nucleic Acids Research . 30 . 1 . 372–4 . 2002 . 11752340 . 99064 . 10.1093/nar/30.1.372.
10. http://fileserver.bioinfo.nat.tu-bs.de/bioinf/ Department of Bioinformatics and Biochemistry – Technical University of Braunschweig Germany
11. http://www.enzymeta.de/ enzymeta
12. http://www.hgmd.cf.ac.uk/ac/index.php HGMD home page
13. http://www.csml.org/tools/cell-illustrator/ Cell System Markup Language (CSML) - Cell Illustrator
14. Web site: Cell Illustartor - new_version.
15. http://europabio.euproject.eu/index.php/kb_3121/oe_1212/oe.html EU Projects at BIOBASE
16. http://findarticles.com/p/articles/mi_m0EIN/is_2007_March_27/ai_n18767478 Net2Drug
17. http://www.biobase.de/pages/index.php?id=438 BIOBASE Biological Databases: SysCo - Functional Analysis
18. http://europabio.euproject.eu/index.php/kb_3121/io_610/io.html Home – Systematic functional analysis of intracellular parasitism as a model of genomes conflict
19. http://www.biobase.de/pages/index.php?id=transistor BIOBASE Biological Databases: TRANSISTOR
20. http://www.geneticsandhealth.com/2008/01/22/gen2phen-web-based-project-to-capture-health-disease-genetic-knowledge/ Gen2Phen
21. Kel . AE . Niehof . M . Matys . V . Zemlin . R . Borlak . J . Genome wide prediction of HNF4alpha functional binding sites by the use of local and global sequence context . Genome Biology . 9 . 2 . R36 . 2008 . 18291023 . 2374721 . 10.1186/gb-2008-9-2-r36 . free .
22. Minovitsky . S . Stegmaier . P . Kel . A . Kondrashov . AS . Dubchak . I . Short sequence motifs, overrepresented in mammalian conserved non-coding sequences . BMC Genomics . 8 . 378 . 2007 . 17945028 . 2176071 . 10.1186/1471-2164-8-378 . free .