Bridging integrator 3 explained

Bridging integrator 3 is a protein that in humans is encoded by the BIN3 gene.^{[1] [2]}

Function

The product of this gene is a member of the BAR domain protein family. The encoded protein is composed solely of a BAR domain which is predicted to form coiled coil structures and proposed to mediate dimerization, sense and induce membrane curvature, and bind small GTPases. BAR domain proteins have been implicated in endocytosis, intracellular transport, and a diverse set of other processes.^[2]

Further reading

• Habermann B . The BAR-domain family of proteins: a case of bending and binding? . EMBO Rep. . 5 . 3 . 250–5 . 2004 . 14993925 . 10.1038/sj.embor.7400105 . 1299016 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Routhier EL, Burn TC, Abbaszade I . Human BIN3 complements the F-actin localization defects caused by loss of Hob3p, the fission yeast homolog of Rvs161p. . J. Biol. Chem. . 276 . 24 . 21670–7 . 2001 . 11274158 . 10.1074/jbc.M101096200 . etal. free .

Notes and References

1. Ren G, Vajjhala P, Lee JS, Winsor B, Munn AL . The BAR domain proteins: molding membranes in fission, fusion, and phagy . Microbiol Mol Biol Rev . 70 . 1 . 37–120 . Mar 2006 . 16524918 . 1393252 . 10.1128/MMBR.70.1.37-120.2006 .
2. Web site: Entrez Gene: BIN3 bridging integrator 3.