BICD2 explained

Bicaudal D cargo adaptor 2 is a protein that in humans is encoded by the BICD2 gene.^{[1] [2]}

This gene is one of two human homologs of Drosophila bicaudal-D and a member of the Bicoid family. It has been implicated in dynein-mediated, minus end-directed motility along microtubules. It has also been reported to be a phosphorylation target of NIMA related kinase 8. Two alternative splice variants have been described.

Mutations in BICD2 are associated with spinal muscular atrophy with lower extremity predominance type 2A and type 2B.

Further reading

• Hoogenraad CC . Mammalian Golgi-associated Bicaudal-D2 functions in the dynein–dynactin pathway by interacting with these complexes . EMBO J. . 20 . 15 . 4041–54 . 2001 . 11483508 . 10.1093/emboj/20.15.4041 . 149157 . Akhmanova A . Howell SA . Dortland . BR . De Zeeuw . CI . Willemsen . R . Visser . P . Grosveld . F . Galjart . N .
• Holland PM . Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2 . J. Biol. Chem. . 277 . 18 . 16229–40 . 2002 . 11864968 . 10.1074/jbc.M108662200 . Milne A . Garka K . Johnson . RS . Willis . C . Sims . JE . Rauch . CT . Bird . TA . Virca . GD . free .
• Short B . The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes . Curr. Biol. . 12 . 20 . 1792–5 . 2003 . 12401177 . 10.1016/S0960-9822(02)01221-6 . Preisinger C . Schaletzky J . Kopajtich . Robert . Barr . Francis A . 14031165 . free. 2002CBio...12.1792S .
• Matanis T . Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex . Nat. Cell Biol. . 4 . 12 . 986–92 . 2003 . 12447383 . 10.1038/ncb891 . Akhmanova A . Wulf P . Del Nery . Elaine . Weide . Thomas . Stepanova . Tatiana . Galjart . Niels . Grosveld . Frank . Goud . Bruno . 7953140 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Hoogenraad CC . Bicaudal D induces selective dynein-mediated microtubule minus end-directed transport . EMBO J. . 22 . 22 . 6004–15 . 2004 . 14609947 . 10.1093/emboj/cdg592 . 275447 . Wulf P . Schiefermeier N . Stepanova . T . Galjart . N . Small . JV . Grosveld . F . De Zeeuw . CI . Akhmanova . A .
• Brill LM . Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry . Anal. Chem. . 76 . 10 . 2763–72 . 2004 . 15144186 . 10.1021/ac035352d . Salomon AR . Ficarro SB . Mukherji . Mridul . Stettler-Gill . Michelle . Peters . Eric C .
• Humphray SJ . DNA sequence and analysis of human chromosome 9 . Nature . 429 . 6990 . 369–74 . 2004 . 15164053 . 10.1038/nature02465 . 2734081 . Oliver K . Hunt AR . Plumb . R. W. . Loveland . J. E. . Howe . K. L. . Andrews . T. D. . Searle . S. . Hunt . S. E. . 2004Natur.429..369H .
• Beausoleil SA . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . Jedrychowski M . Schwartz D . Elias . JE . Villén . J . Li . J . Cohn . MA . Cantley . LC . Gygi . SP . 2004PNAS..10112130B . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Rush J . Immunoaffinity profiling of tyrosine phosphorylation in cancer cells . Nat. Biotechnol. . 23 . 1 . 94–101 . 2005 . 15592455 . 10.1038/nbt1046 . Moritz A . Lee KA . Guo . Ailan . Goss . Valerie L . Spek . Erik J . Zhang . Hui . Zha . Xiang-Ming . Polakiewicz . Roberto D . 7200157 .
• Book: Fuchs E, Short B, Barr FA . GTPases Regulating Membrane Targeting and Fusion . Assay and Properties of Rab6 Interaction with Dynein–Dynactin Complexes . 403 . 607–18 . 16473624 . 10.1016/S0076-6879(05)03053-3 . Methods in Enzymology . 2005 . 978-0-12-182808-0 . https://archive.org/details/gtpasesregulatin403balc/page/607 .
• Beausoleil SA . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . Villén J . Gerber SA . Rush . John . Gygi . Steven P . 14294292 .
• Olsen JV . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . Blagoev B . Gnad F . Macek . Boris . Kumar . Chanchal . Mortensen . Peter . Mann . Matthias . 7827573 . free.

Notes and References

1. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Res . 5 . 3 . 169–76 . Dec 1998 . 9734811 . 10.1093/dnares/5.3.169 . free .
2. Web site: Entrez Gene: BICD2 bicaudal D homolog 2 (Drosophila).