BICD1 explained

Bicaudal D cargo adaptor 1 is a protein that in humans is encoded by the BICD1 gene.^{[1] [2]}

Function

This gene is one of two human homologs of Drosophila bicaudal-D. It has been implicated in COPI-independent membrane transport from the Golgi apparatus to the endoplasmic reticulum. Two alternative splice variants have been described. Other alternative splice variants that encode different protein isoforms have been described but their full-length nature has not been determined.

Interactions

BICD1 has been shown to interact with RAB6A.^{[3] [4]}

Further reading

• Barr FA, Short B . Golgins in the structure and dynamics of the Golgi apparatus . Current Opinion in Cell Biology . 15 . 4 . 405–13 . August 2003 . 12892780 . 10.1016/S0955-0674(03)00054-1 .
• Claussen M, Suter B . BicD-dependent localization processes: from Drosophilia development to human cell biology . Annals of Anatomy - Anatomischer Anzeiger . 187 . 5–6 . 539–53 . November 2005 . 16320833 . 10.1016/j.aanat.2005.07.004 .
• Baens M, Aerssens J, van Zand K, Van den Berghe H, Marynen P . Isolation and regional assignment of human chromosome 12p cDNAs . Genomics . 29 . 1 . 44–52 . September 1995 . 8530100 . 10.1006/geno.1995.1213 .
• Short B, Preisinger C, Schaletzky J, Kopajtich R, Barr FA . The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes . Current Biology . 12 . 20 . 1792–5 . October 2002 . 12401177 . 10.1016/S0960-9822(02)01221-6 . 14031165 . free . 2002CBio...12.1792S .
• Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T, Galjart N, Grosveld F, Goud B, De Zeeuw CI, Barnekow A, Hoogenraad CC . Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex . Nature Cell Biology . 4 . 12 . 986–92 . December 2002 . 12447383 . 10.1038/ncb891 . 7953140 .
• Tomsig JL, Snyder SL, Creutz CE . Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif . The Journal of Biological Chemistry . 278 . 12 . 10048–54 . Mar 2003 . 12522145 . 10.1074/jbc.M212632200 . free .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Research . 16 . 1 . 55–65 . Jan 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Book: Fuchs E, Short B, Barr FA . Assay and Properties of Rab6 Interaction with Dynein–Dynactin Complexes . GTPases Regulating Membrane Targeting and Fusion . Methods in Enzymology . 403 . 607–18 . 2006 . 16473624 . 10.1016/S0076-6879(05)03053-3 . 978-0-12-182808-0 .
• Moorhead AR, Rzomp KA, Scidmore MA . The Rab6 effector Bicaudal D1 associates with Chlamydia trachomatis inclusions in a biovar-specific manner . Infection and Immunity . 75 . 2 . 781–91 . Feb 2007 . 17101644 . 1828475 . 10.1128/IAI.01447-06 .
• Fumoto K, Hoogenraad CC, Kikuchi A . GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome . The EMBO Journal . 25 . 24 . 5670–82 . December 2006 . 17139249 . 1698904 . 10.1038/sj.emboj.7601459 .
• Wanschers BF, van de Vorstenbosch R, Schlager MA, Splinter D, Akhmanova A, Hoogenraad CC, Wieringa B, Fransen JA . A role for the Rab6B Bicaudal-D1 interaction in retrograde transport in neuronal cells . Experimental Cell Research . 313 . 16 . 3408–20 . Oct 2007 . 17707369 . 10.1016/j.yexcr.2007.05.032 .

Notes and References

1. Baens M, Marynen P . A human homologue (BICD1) of the Drosophila bicaudal-D gene . Genomics . 45 . 3 . 601–6 . Nov 1997 . 9367685 . 10.1006/geno.1997.4971 .
2. Web site: Entrez Gene: BICD1 bicaudal D homolog 1 (Drosophila).
3. Short B, Preisinger C, Schaletzky J, Kopajtich R, Barr FA . The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes . Current Biology . 12 . 20 . 1792–5 . Oct 2002 . 12401177 . 10.1016/S0960-9822(02)01221-6 . 14031165 . free . 2002CBio...12.1792S .
4. Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T, Galjart N, Grosveld F, Goud B, De Zeeuw CI, Barnekow A, Hoogenraad CC . Casper Hoogenraad . Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex . Nature Cell Biology . 4 . 12 . 986–92 . December 2002 . 12447383 . 10.1038/ncb891 . 7953140 .