BHLHB2 explained

Class E basic helix-loop-helix protein 40 is a protein that in humans is encoded by the BHLHE40 gene.^{[1] [2] [3] [4]}

Function

DEC1 encodes a basic helix-loop-helix protein expressed in various tissues. Expression in the chondrocytes is responsive to the addition of Bt2cAMP. Differentiated embryo chondrocyte expressed gene 1 is believed to be involved in the control of cell differentiation.^[4]

Further reading

• Teramoto M, Nakamasu K, Noshiro M, Matsuda Y, Gotoh O, Shen M, Tsutsumi S, Kawamoto T, Iwamoto Y, Kato Y . Gene structure and chromosomal location of a human bHLH transcriptional factor DEC1 x Stra13 x SHARP-2/BHLHB2 . Journal of Biochemistry . 129 . 3 . 391–6 . Mar 2001 . 11226878 . 10.1093/oxfordjournals.jbchem.a002869 .
• Ivanova AV, Ivanov SV, Danilkovitch-Miagkova A, Lerman MI . Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway . The Journal of Biological Chemistry . 276 . 18 . 15306–15 . May 2001 . 11278694 . 10.1074/jbc.M010516200 . free .
• Sun H, Lu B, Li RQ, Flavell RA, Taneja R . Defective T cell activation and autoimmune disorder in Stra13-deficient mice . Nature Immunology . 2 . 11 . 1040–7 . Nov 2001 . 11668339 . 10.1038/ni721 . 26633291 .
• Yoon DY, Buchler P, Saarikoski ST, Hines OJ, Reber HA, Hankinson O . Identification of genes differentially induced by hypoxia in pancreatic cancer cells . Biochemical and Biophysical Research Communications . 288 . 4 . 882–6 . Nov 2001 . 11688991 . 10.1006/bbrc.2001.5867 .
• Li Y, Zhang H, Xie M, Hu M, Ge S, Yang D, Wan Y, Yan B . Abundant expression of Dec1/stra13/sharp2 in colon carcinoma: its antagonizing role in serum deprivation-induced apoptosis and selective inhibition of procaspase activation . The Biochemical Journal . 367 . Pt 2 . 413–22 . Oct 2002 . 12119049 . 1222902 . 10.1042/BJ20020514 .
• St-Pierre B, Flock G, Zacksenhaus E, Egan SE . Stra13 homodimers repress transcription through class B E-box elements . The Journal of Biological Chemistry . 277 . 48 . 46544–51 . Nov 2002 . 12297495 . 10.1074/jbc.M111652200 . free .
• Miyazaki K, Kawamoto T, Tanimoto K, Nishiyama M, Honda H, Kato Y . Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes . The Journal of Biological Chemistry . 277 . 49 . 47014–21 . Dec 2002 . 12354771 . 10.1074/jbc.M204938200 . free .
• Shen M, Yoshida E, Yan W, Kawamoto T, Suardita K, Koyano Y, Fujimoto K, Noshiro M, Kato Y . Basic helix-loop-helix protein DEC1 promotes chondrocyte differentiation at the early and terminal stages . The Journal of Biological Chemistry . 277 . 51 . 50112–20 . Dec 2002 . 12384505 . 10.1074/jbc.M206771200 . free .
• Honma S, Kawamoto T, Takagi Y, Fujimoto K, Sato F, Noshiro M, Kato Y, Honma K . Dec1 and Dec2 are regulators of the mammalian molecular clock . Nature . 419 . 6909 . 841–4 . Oct 2002 . 12397359 . 10.1038/nature01123 . 2002Natur.419..841H . 4426418 .
• Li Y, Xie M, Song X, Gragen S, Sachdeva K, Wan Y, Yan B . DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter . The Journal of Biological Chemistry . 278 . 19 . 16899–907 . May 2003 . 12624110 . 10.1074/jbc.M300596200 . free .
• Giatromanolaki A, Koukourakis MI, Sivridis E, Turley H, Wykoff CC, Gatter KC, Harris AL . DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer . The Journal of Pathology . 200 . 2 . 222–8 . Jun 2003 . 12754744 . 10.1002/path.1330 . 26744393 .
• Ivanova AV, Ivanov SV, Zhang X, Ivanov VN, Timofeeva OA, Lerman MI . STRA13 interacts with STAT3 and modulates transcription of STAT3-dependent targets . Journal of Molecular Biology . 340 . 4 . 641–53 . Jul 2004 . 15223310 . 10.1016/j.jmb.2004.05.025 .
• Sato F, Kawamoto T, Fujimoto K, Noshiro M, Honda KK, Honma S, Honma K, Kato Y . Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1 . European Journal of Biochemistry . 271 . 22 . 4409–19 . Nov 2004 . 15560782 . 10.1111/j.1432-1033.2004.04379.x . free .
• Ivanova AV, Ivanov SV, Lerman ML . Association, mutual stabilization, and transcriptional activity of the STRA13 and MSP58 proteins . Cellular and Molecular Life Sciences . 62 . 4 . 471–84 . Feb 2005 . 15719173 . 10.1007/s00018-004-4423-2 . 6528873 .
• Ivanova A, Liao SY, Lerman MI, Ivanov S, Stanbridge EJ . STRA13 expression and subcellular localisation in normal and tumour tissues: implications for use as a diagnostic and differentiation marker . Journal of Medical Genetics . 42 . 7 . 565–76 . Jul 2005 . 15994878 . 1736099 . 10.1136/jmg.2004.029835 .
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE . A human protein-protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–68 . Sep 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . 11858/00-001M-0000-0010-8592-0 . 8235923 . free .

Notes and References

1. Shen M, Kawamoto T, Yan W, Nakamasu K, Tamagami M, Koyano Y, Noshiro M, Kato Y . Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes . Biochemical and Biophysical Research Communications . 236 . 2 . 294–8 . Jul 1997 . 9240428 . 10.1006/bbrc.1997.6960 .
2. Antonevich T, Taneja R . Assignment1 of the human Stra13 gene (STRA13) to chromosome 3p26 by in situ hybridization . Cytogenetics and Cell Genetics . 85 . 3–4 . 254–5 . Oct 1999 . 10449910 . 10.1159/000015305 . 25761427 .
3. Stevens JD, Roalson EH, Skinner MK . Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation . Differentiation; Research in Biological Diversity . 76 . 9 . 1006–22 . Nov 2008 . 18557763 . 5728086. 10.1111/j.1432-0436.2008.00285.x .
4. Web site: Entrez Gene: BHLHB2 basic helix-loop-helix domain containing, class B, 2.