BEX4 explained

Brain expressed, X-linked 4 is a protein that in humans is encoded by the BEX4 gene.^[1]

This gene is a member of the brain expressed X-linked gene family. Proteins encoded by other members of this family act as transcription elongation factors that allow RNA polymerase II to escape pausing during elongation. Multiple alternatively spliced variants encoding the same protein have been identified.

Further reading

• Chien J, Staub J, Avula R, Zhang H, Liu W, Hartmann LC, Kaufmann SH, Smith DI, Shridhar V . 6 . Epigenetic silencing of TCEAL7 (Bex4) in ovarian cancer . Oncogene . 24 . 32 . 5089–5100 . July 2005 . 15870691 . 10.1038/sj.onc.1208700 . 34533769 .
• Gao W, Li JZ, Chen SQ, Chu CY, Chan JY, Wong TS . Decreased brain-expressed X-linked 4 (BEX4) expression promotes growth of oral squamous cell carcinoma . Journal of Experimental & Clinical Cancer Research . 35 . 1 . 92 . June 2016 . 27297407 . 4906687 . 10.1186/s13046-016-0355-6 . free .
• Lee JK, Lee J, Go H, Lee CG, Kim S, Kim HS, Cho H, Choi KS, Ha GH, Lee CW . 6 . Oncogenic microtubule hyperacetylation through BEX4-mediated sirtuin 2 inhibition . Cell Death & Disease . 7 . 8 . e2336 . August 2016 . 27512957 . 5108325 . 10.1038/cddis.2016.240 .
• Yu W, Yaping L, Mingjun W, Jie H, Xiaogang L, Gang L . BEX4 upregulation alters Sertoli cell growth properties and protein expression profiles: An explanation for cadmium-induced testicular Sertoli cell injury . Journal of Biochemical and Molecular Toxicology . 31 . 7 . July 2017 . e21908 . 28295929 . 10.1002/jbt.21908 . 27130849 .
• Zhao Z, Li J, Tan F, Gao S, He J . mTOR up-regulation of BEX4 promotes lung adenocarcinoma cell proliferation by potentiating OCT4 . Biochemical and Biophysical Research Communications . 500 . 2 . 302–309 . June 2018 . 29660335 . 10.1016/j.bbrc.2018.04.064 . 5045928 .
• Lee JK, Ha GH, Kim HS, Lee CW . Oncogenic potential of BEX4 is conferred by Polo-like kinase 1-mediated phosphorylation . Experimental & Molecular Medicine . 50 . 10 . 1–12 . October 2018 . 30367032 . 6203768 . 10.1038/s12276-018-0168-0 .
• Zhu C, Xiao D . Aberrant brain-expressed X-linked 4 (BEX4) expression is a novel prognostic biomarker in gastric cancer . Medicine . 99 . 47 . e23133 . November 2020 . 33217815 . 7676604 . 10.1097/MD.0000000000023133 .
• Lee S, Kang H, Shin E, Jeon J, Youn H, Youn B . BEX1 and BEX4 Induce GBM Progression through Regulation of Actin Polymerization and Activation of YAP/TAZ Signaling . International Journal of Molecular Sciences . 22 . 18 . September 2021 . 9845 . 34576008 . 8471324 . 10.3390/ijms22189845 . free .

Notes and References

1. Web site: Entrez Gene: Brain expressed, X-linked 4 . 2013-04-04 .