BET1 explained

BET1 homolog is a protein that in humans is encoded by the BET1 gene.^{[1] [2] [3]}

This gene encodes a golgi-associated membrane protein that participates in vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex. The encoded protein functions as a soluble N-ethylaleimide-sensitive factor attachment protein receptor and may be involved in the docking of ER-derived vesicles with the cis-Golgi membrane. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length nature has not been determined.^[3]

Further reading

• Olsen JV, Blagoev B, Gnad F . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . etal. free .
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Hillier LW, Fulton RS, Fulton LA . The DNA sequence of human chromosome 7. . Nature . 424 . 6945 . 157–64 . 2003 . 12853948 . 10.1038/nature01782 . 2003Natur.424..157H . etal. free .
• Scherer SW, Cheung J, MacDonald JR . Human chromosome 7: DNA sequence and biology. . Science . 300 . 5620 . 767–72 . 2003 . 12690205 . 2882961 . 10.1126/science.1083423 . 2003Sci...300..767S . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Zhang T, Hong W . Ykt6 forms a SNARE complex with syntaxin 5, GS28, and Bet1 and participates in a late stage in endoplasmic reticulum-Golgi transport. . J. Biol. Chem. . 276 . 29 . 27480–7 . 2001 . 11323436 . 10.1074/jbc.M102786200 . free .
• Toward a complete human genome sequence. . Genome Res. . 8 . 11 . 1097–108 . 1999 . 9847074 . 10.1101/gr.8.11.1097. Sanger Centre . The . Washington University Genome Sequencing Cente . The . free .
• Hay JC, Chao DS, Kuo CS, Scheller RH . Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells. . Cell . 89 . 1 . 149–58 . 1997 . 9094723 . 10.1016/S0092-8674(00)80191-9 . 8682509 . free .
• Hay JC, Hirling H, Scheller RH . Mammalian vesicle trafficking proteins of the endoplasmic reticulum and Golgi apparatus. . J. Biol. Chem. . 271 . 10 . 5671–9 . 1996 . 8621431 . 10.1074/jbc.271.10.5671 . free .

Notes and References

1. Zhang T, Wong SH, Tang BL, Xu Y, Peter F, Subramaniam VN, Hong W . The mammalian protein (rbet1) homologous to yeast Bet1p is primarily associated with the pre-Golgi intermediate compartment and is involved in vesicular transport from the endoplasmic reticulum to the Golgi apparatus . J Cell Biol . 139 . 5 . 1157–68 . Dec 1997 . 9382863 . 2140212 . 10.1083/jcb.139.5.1157 .
2. Waters MG, Pfeffer SR . Membrane tethering in intracellular transport . Curr Opin Cell Biol . 11 . 4 . 453–9 . Nov 1999 . 10449330 . 10.1016/S0955-0674(99)80065-9 .
3. Web site: Entrez Gene: BET1 BET1 homolog (S. cerevisiae).