BDPC explained

BDPC (systematic name 4-(4-bromophenyl)-4-(dimethylamino)-1-(2-phenylethyl)cyclohexanol; also known as bromadol) is a potent fully synthetic opioid with a distinctive arylcyclohexylamine chemical structure. It was developed by Daniel Lednicer at Upjohn in the 1970s.^[1] Initial studies estimated that it was around 10,000 times the potency of morphine in animal models.^[2] However, later studies using more modern techniques assigned a value of 504 times the potency of morphine for the more active trans-isomer.^[3] This drug was first seized along with three kilograms of acetylfentanyl in an April 25, 2013 police action in Montreal, Canada,^[4] and has reportedly continued to be available on the designer drug market internationally.^{[5] [6]} Analogues where the para-bromine is replaced by chlorine or a methyl group retain similar activity, while the meta-hydroxyl derivative demonstrated robust antagonist activity.^{[7] [8]}

See also

• 3-HO-PCP
• 4-Keto-PCP
• C-8813
• Cebranopadol
• Ciramadol
• Dimetamine
• Faxeladol
• Profadol
• Tapentadol
• Tramadol

Notes and References

1. US . 4366172 . 4-Amino-cyclohexanols, their pharmaceutical compositions and methods of use . Daniel. Lednicer . . 1982-12-28 .
2. Lednicer D, VonVoigtlander PF . 4-(p-Bromophenyl)-4-(dimethylamino)-1-phenethylcyclohexanol, an extremely potent representative of a new analgesic series . . 22 . 10 . 1157–8 . October 1979 . 513062 . 10.1021/jm00196a001 .
3. Liu ZH, Jin WQ, Dai QY, Chen XJ, Zhang HP, Chi ZQ . Opioid activity of C8813, a novel and potent opioid analgesic . . 73 . 2 . 233–41 . May 2003 . 12738037 . 10.1016/S0024-3205(03)00263-7 .
4. News: Extremely potent painkiller hits Montreal black market . CBC News . May 13, 2013.
5. Sharma KK, Hales TG, Rao VJ, NicDaeid N, McKenzie C . The search for the "next" euphoric non-fentanil novel synthetic opioids on the illicit drugs market: current status and horizon scanning . Forensic Toxicology . 37 . 1 . 1–16 . January 2019 . 30636980 . 10.1007/s11419-018-0454-5 . 6314991 .
6. Vandeputte MM, Cannaert A, Stove CP . In vitro functional characterization of a panel of non-fentanyl opioid new psychoactive substances . . 94 . 11 . 3819–3830 . November 2020 . 32734307 . 10.1007/s00204-020-02855-7 . 220881657 . 1854/LU-8687070 . free .
7. Lednicer D, VonVoigtlander PF, Emmert DE . 4-amino-4-arylcyclohexanones and their derivatives: a novel class of analgesics. 2. Modification of the carbonyl function . . 24 . 4 . 404–8 . April 1981 . 7265128 . 10.1021/jm00136a010 .
8. Lednicer D, Von Voigtlander PF, Emmert DE . 4-aryl-4-aminocyclohexanones and their derivatives, a novel class of analgesics. 3. m-Hydroxyphenyl derivates . . 24 . 3 . 341–6 . March 1981 . 7265120 . 10.1021/jm00135a019 .