BDP1 explained

Transcription factor TFIIIB component B″ homolog also known as TFIIIB150 is a protein that in humans is encoded by the BDP1 gene.^{[1] [2] [3]}

Function

TFIIIB150 is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by casein kinase 2 during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription.

Further reading

• Chu WM, Wang Z, Roeder RG, Schmid CW . RNA polymerase III transcription repressed by Rb through its interactions with TFIIIB and TFIIIC2 . J. Biol. Chem. . 272 . 23 . 14755–61 . 1997 . 9169441 . 10.1074/jbc.272.23.14755 . free .
• Wang Z, Roeder RG . Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation . Genes Dev. . 11 . 10 . 1315–26 . 1997 . 9171375 . 10.1101/gad.11.10.1315 . free .
• Nagase T, Ishikawa K, Kikuno R . Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 6 . 5 . 337–45 . 2000 . 10574462 . 10.1093/dnares/6.5.337 . etal. free .
• Kelter AR, Herchenbach J, Wirth B . The transcription factor-like nuclear regulator (TFNR) contains a novel 55-amino-acid motif repeated nine times and maps closely to SMN1 . Genomics . 70 . 3 . 315–26 . 2001 . 11161782 . 10.1006/geno.2000.6396 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Hu P, Wu S, Hernandez N . A minimal RNA polymerase III transcription system from human cells reveals positive and negative regulatory roles for CK2 . Mol. Cell . 12 . 3 . 699–709 . 2003 . 14527415 . 10.1016/j.molcel.2003.08.011 . free .
• Fairley JA, Scott PH, White RJ . TFIIIB is phosphorylated, disrupted and selectively released from tRNA promoters during mitosis in vivo . EMBO J. . 22 . 21 . 5841–50 . 2003 . 14592981 . 10.1093/emboj/cdg544 . 275401 .
• Weser S, Gruber C, Hafner HM . Transcription factor (TF)-like nuclear regulator, the 250-kDa form of Homo sapiens TFIIIB", is an essential component of human TFIIIC1 activity . J. Biol. Chem. . 279 . 26 . 27022–9 . 2004 . 15096501 . 10.1074/jbc.M312790200 . etal. free .
• Suzuki Y, Yamashita R, Shirota M . Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions . Genome Res. . 14 . 9 . 1711–8 . 2004 . 15342556 . 10.1101/gr.2435604 . 515316 . etal.
• Hu P, Samudre K, Wu S . CK2 phosphorylation of Bdp1 executes cell cycle-specific RNA polymerase III transcription repression . Mol. Cell . 16 . 1 . 81–92 . 2004 . 15469824 . 10.1016/j.molcel.2004.09.008 . etal. free .
• Schoenen F, Wirth B . The zinc finger protein ZNF297B interacts with BDP1, a subunit of TFIIIB . Biol. Chem. . 387 . 3 . 277–84 . 2006 . 16542149 . 10.1515/BC.2006.037 . 28560128 .
• Johnson SS, Zhang C, Fromm J . Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases . Mol. Cell . 26 . 3 . 367–79 . 2007 . 17499043 . 10.1016/j.molcel.2007.03.021 . etal. free .

Notes and References

1. Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O . Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res . 7 . 6 . 347–55 . Feb 2001 . 11214970 . 10.1093/dnares/7.6.347 . free .
2. Schramm L, Pendergrast PS, Sun Y, Hernandez N . Different human TFIIIB activities direct RNA polymerase III transcription from TATA-containing and TATA-less promoters . Genes Dev . 14 . 20 . 2650–63 . Nov 2000 . 11040218 . 316990 . 10.1101/gad.836400 .
3. Web site: Entrez Gene: BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB.