BD1018 explained

BD1018 or (S)-2-[2-(3,4-dichlorophenyl)ethyl]octahydropyrrolo[1,2-a]pyrazine is a selective sigma receptor ligand, with a reported binding affinity of K_i = 5 ± 0.7 nM for the sigma-1 receptor and approximately 10 times selectivity over the sigma-2 receptor.^[1] Unlike its enantiomer, BD1031, BD1018 acts as a sigma receptor antagonist.

Consistent with other reported sigma receptor antagonists, BD1018 decreases the behavioural toxicity of cocaine in Swiss Webster mice.

See also

• BD1008
• BD1031

Notes and References

1. Matsumoto RR, McCracken KA, Friedman MJ, Pouw B, De Costa BR, Bowen WD . Conformationally restricted analogs of BD1008 and an antisense oligodeoxynucleotide targeting sigma1 receptors produce anti-cocaine effects in mice . Eur. J. Pharmacol. . 419 . 2–3 . 163–74 . 2001 . 11426838. 10.1016/s0014-2999(01)00968-2.