BCL2L14 explained

Apoptosis facilitator Bcl-2-like protein 14 is a protein that in humans is encoded by the BCL2L14 gene.^{[1] [2]}

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Overexpression of this gene has been shown to induce apoptosis in cells. Four alternatively spliced transcript variants, which encode three distinct isoforms, have been reported for this gene.

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Montpetit A, Boily G, Sinnett D . A detailed transcriptional map of the chromosome 12p12 tumour suppressor locus . European Journal of Human Genetics . 10 . 1 . 62–71 . 2002 . 11896457 . 10.1038/sj.ejhg.5200766 . free .
• Kutsenko AS, Gizatullin RZ, Al-Amin AN . NotI flanking sequences: a tool for gene discovery and verification of the human genome . Nucleic Acids Res. . 30 . 14 . 3163–70 . 2002 . 12136098 . 10.1093/nar/gkf428 . 135748 . etal.
• Ozalp SS, Yalcin OT, Tanir HM . Bcl-2 expression in preinvasive and invasive cervical lesions . Eur. J. Gynaecol. Oncol. . 23 . 5 . 419–22 . 2003 . 12440815 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proceedings of the National Academy of Sciences of the United States of America . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Montpetit A, Larose J, Boily G . Mutational and expression analysis of the chromosome 12p candidate tumor suppressor genes in pre-B acute lymphoblastic leukemia . Leukemia . 18 . 9 . 1499–504 . 2004 . 15284860 . 10.1038/sj.leu.2403441 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Soung YH, Lee JW, Park WS . BH3 domain mutation of proapoptotic genes Bad, Bmf and Bcl-G is rare in transitional cell carcinomas of the urinary bladder . Pathology . 38 . 1 . 33–4 . 2006 . 16484005 . 10.1080/00313020500455811 . 32022854 . etal.
• Lin ML, Park JH, Nishidate T . Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family . Breast Cancer Res. . 9 . 1 . R17 . 2007 . 17280616 . 10.1186/bcr1650 . 1851384 . etal . free .
• Yoo NJ, Soung YH, Lee SH . Mutational analysis of the BH3 domains of proapoptotic Bcl-2 family genes Bad, Bmf and Bcl-G in laryngeal squamous cell carcinomas . Tumori . 93 . 2 . 195–7 . 2007 . 17557568 . 10.1177/030089160709300214. 21247583 . etal.

Notes and References

1. Guo B, Godzik A, Reed JC . Bcl-G, a novel pro-apoptotic member of the Bcl-2 family . J Biol Chem . 276 . 4 . 2780–5 . May 2001. 11054413 . 10.1074/jbc.M005889200 . free .
2. Web site: Entrez Gene: BCL2L14 BCL2-like 14 (apoptosis facilitator).