BCL2L10 explained

Bcl-2-like protein 10 is a protein that in humans is encoded by the BCL2L10 gene.^{[1] [2] [3]}

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus preventing caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASP9 related apoptotic pathway.

Further reading

• van Oirschot JT . Diva vaccines that reduce virus transmission . J. Biotechnol. . 73 . 2–3 . 195–205 . 1999 . 10486928 . 10.1016/S0168-1656(99)00121-2 .
• Pan G, O'Rourke K, Dixit VM . Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex . J. Biol. Chem. . 273 . 10 . 5841–5 . 1998 . 9488720 . 10.1074/jbc.273.10.5841 . free .
• Ke N, Godzik A, Reed JC . Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak . J. Biol. Chem. . 276 . 16 . 12481–4 . 2001 . 11278245 . 10.1074/jbc.C000871200 . free .
• Naumann U, Weit S, Wischhusen J, Weller M . Diva/Boo is a negative regulator of cell death in human glioma cells . FEBS Lett. . 505 . 1 . 23–6 . 2001 . 11557035 . 10.1016/S0014-5793(01)02768-5 . free .
• Aouacheria A . Nrh, a human homologue of Nr-13 associates with Bcl-Xs and is an inhibitor of apoptosis . Oncogene . 20 . 41 . 5846–55 . 2001 . 11593390 . 10.1038/sj.onc.1204740 . vanc. Arnaud E . Venet S . 3 . Lalle . Philippe . Gouy . Manolo . Rigal . Dominique . Gillet . Germain . free .
• Zhang H, Holzgreve W, De Geyter C . Bcl2-L-10, a novel anti-apoptotic member of the Bcl-2 family, blocks apoptosis in the mitochondria death pathway but not in the death receptor pathway . Hum. Mol. Genet. . 10 . 21 . 2329–39 . 2002 . 11689480 . 10.1093/hmg/10.21.2329 . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Li Z, Takeuchi S, Ohara N, Maruo T . Paradoxically abundant expression of Bcl-2 and adrenomedullin in invasive cervical squamous carcinoma . Int. J. Clin. Oncol. . 8 . 2 . 83–9 . 2003 . 12720100 . 10.1007/s101470300015 . 24180107 .
• Kang Y . NM23-H2 involves in negative regulation of Diva and Bcl2L10 in apoptosis signaling . Biochem. Biophys. Res. Commun. . 359 . 1 . 76–82 . 2007 . 17532299 . 10.1016/j.bbrc.2007.05.090 . vanc. Lee DC . Han J . 3 . Yoon . Seongmin . Won . Miae . Yeom . Ji-Hyun . Seong . Maeng-Je . Ko . Jeong-Jae . Lee . Kyung-Ah .
• Guillemin Y . Oocytes and early embryos selectively express the survival factor BCL2L10 . J. Mol. Med. . 87 . 9 . 923–40 . 2009 . 19551325 . 10.1007/s00109-009-0495-7 . vanc. Lalle P . Gillet G . 3 . Guerin . Jean-François . Hamamah . Samir . Aouacheria . Abdel . 23491033 .

Notes and References

1. Inohara N, Gourley TS, Carrio R, Muniz M, Merino J, Garcia I, Koseki T, Hu Y, Chen S, Nunez G . Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death . J Biol Chem . 273 . 49 . 32479–86 . Jan 1999 . 9829980 . 10.1074/jbc.273.49.32479 . free .
2. Song Q, Kuang Y, Dixit VM, Vincenz C . Boo, a novel negative regulator of cell death, interacts with Apaf-1 . EMBO J . 18 . 1 . 167–78 . Feb 1999 . 9878060 . 1171112 . 10.1093/emboj/18.1.167 .
3. Web site: Entrez Gene: BCL2L10 BCL2-like 10 (apoptosis facilitator).