Bcl-2-like protein 1 explained

Bcl-2-like protein 1 is a protein encoded in humans by the BCL2L1 gene. Through alternative splicing, the gene encodes both of the human proteins Bcl-xL and Bcl-xS.[1]

Function

The protein encoded by this gene belongs to the Bcl-2 protein family. Bcl-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (voltage-dependent anion channels (VDACs) opening. VDACs regulate mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform (Bcl-xL) acts as an apoptotic inhibitor and the shorter form (Bcl-xS) acts as an apoptotic activator.[1] [2]

Interactions

BCL2-like 1 (gene) has been shown to interact with:

Further reading

Notes and References

  1. Boise LH, González-García M, Postema CE, Ding L, Lindsten T, Turka LA, Mao X, Nuñez G, Thompson CB . bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death . Cell . 74 . 4 . 597–608 . Aug 1993 . 8358789 . 10.1016/0092-8674(93)90508-N . 2027.42/30629 . 13542617 . free .
  2. Web site: Entrez Gene: BCL2L1 BCL2-like 1.
  3. Hu Y, Benedict MA, Wu D, Inohara N, Núñez G . Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation . Proceedings of the National Academy of Sciences of the United States of America . 95 . 8 . 4386–91 . Apr 1998 . 9539746 . 22498 . 10.1073/pnas.95.8.4386 . 1998PNAS...95.4386H . free .
  4. Pan G, O'Rourke K, Dixit VM . Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex . The Journal of Biological Chemistry . 273 . 10 . 5841–5 . Mar 1998 . 9488720 . 10.1074/jbc.273.10.5841 . free .
  5. Zhang H, Nimmer P, Rosenberg SH, Ng SC, Joseph M . Development of a high-throughput fluorescence polarization assay for Bcl-x(L) . Analytical Biochemistry . 307 . 1 . 70–5 . Aug 2002 . 12137781 . 10.1016/S0003-2697(02)00028-3 .
  6. Whitfield J, Harada K, Bardelle C, Staddon JM . High-throughput methods to detect dimerization of Bcl-2 family proteins . Analytical Biochemistry . 322 . 2 . 170–8 . Nov 2003 . 14596824 . 10.1016/j.ab.2003.07.014 .
  7. Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI, Adams JM, Huang DC . Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins . Genes & Development . 19 . 11 . 1294–305 . Jun 2005 . 15901672 . 1142553 . 10.1101/gad.1304105 .
  8. Degterev A, Lugovskoy A, Cardone M, Mulley B, Wagner G, Mitchison T, Yuan J . Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL . Nature Cell Biology . 3 . 2 . 173–82 . Feb 2001 . 11175750 . 10.1038/35055085 . 32934759 .
  9. Ng FW, Nguyen M, Kwan T, Branton PE, Nicholson DW, Cromlish JA, Shore GC . p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum . The Journal of Cell Biology . 139 . 2 . 327–38 . Oct 1997 . 9334338 . 2139787 . 10.1083/jcb.139.2.327 .
  10. O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S, Huang DC . Bim: a novel member of the Bcl-2 family that promotes apoptosis . The EMBO Journal . 17 . 2 . 384–95 . Jan 1998 . 9430630 . 1170389 . 10.1093/emboj/17.2.384 .
  11. Hsu SY, Lin P, Hsueh AJ . BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members . Molecular Endocrinology . 12 . 9 . 1432–40 . Sep 1998 . 9731710 . 10.1210/mend.12.9.0166 . free .
  12. Ray R, Chen G, Vande Velde C, Cizeau J, Park JH, Reed JC, Gietz RD, Greenberg AH . BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites . The Journal of Biological Chemistry . 275 . 2 . 1439–48 . Jan 2000 . 10625696 . 10.1074/jbc.275.2.1439 . free .
  13. Qin W, Hu J, Guo M, Xu J, Li J, Yao G, Zhou X, Jiang H, Zhang P, Shen L, Wan D, Gu J . BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis . Biochemical and Biophysical Research Communications . 308 . 2 . 379–85 . Aug 2003 . 12901880 . 10.1016/S0006-291X(03)01387-1 .
  14. Yasuda M, Han JW, Dionne CA, Boyd JM, Chinnadurai G . BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3 . Cancer Research . 59 . 3 . 533–7 . Feb 1999 . 9973195 .
  15. Jin Z, Xin M, Deng X . Survival function of protein kinase C as a novel nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-activated bad kinase . The Journal of Biological Chemistry . 280 . 16 . 16045–52 . Apr 2005 . 15705582 . 10.1074/jbc.M413488200 . free .
  16. Yang E, Zha J, Jockel J, Boise LH, Thompson CB, Korsmeyer SJ . Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death . Cell . 80 . 2 . 285–91 . Jan 1995 . 7834748 . 10.1016/0092-8674(95)90411-5 . 10343291 . free .
  17. Petros AM, Nettesheim DG, Wang Y, Olejniczak ET, Meadows RP, Mack J, Swift K, Matayoshi ED, Zhang H, Thompson CB, Fesik SW . Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies . Protein Science . 9 . 12 . 2528–34 . Dec 2000 . 11206074 . 2144516 . 10.1110/ps.9.12.2528 .
  18. Chattopadhyay A, Chiang CW, Yang E . BAD/BCL-[X(L)] heterodimerization leads to bypass of G0/G1 arrest . Oncogene . 20 . 33 . 4507–18 . Jul 2001 . 11494146 . 10.1038/sj.onc.1204584 . free .
  19. Iwahashi H, Eguchi Y, Yasuhara N, Hanafusa T, Matsuzawa Y, Tsujimoto Y . Synergistic anti-apoptotic activity between Bcl-2 and SMN implicated in spinal muscular atrophy . Nature . 390 . 6658 . 413–7 . Nov 1997 . 9389483 . 10.1038/37144 . 1997Natur.390..413I . 1936633 .
  20. Komatsu K, Wharton W, Hang H, Wu C, Singh S, Lieberman HB, Pledger WJ, Wang HG . PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition . Oncogene . 19 . 46 . 5291–7 . Nov 2000 . 11077446 . 10.1038/sj.onc.1203901 . 8931364 .
  21. Strobel T, Tai YT, Korsmeyer S, Cannistra SA . BAD partly reverses paclitaxel resistance in human ovarian cancer cells . Oncogene . 17 . 19 . 2419–27 . Nov 1998 . 9824152 . 10.1038/sj.onc.1202180 . 44240363 .
  22. Sedlak TW, Oltvai ZN, Yang E, Wang K, Boise LH, Thompson CB, Korsmeyer SJ . Multiple Bcl-2 family members demonstrate selective dimerizations with Bax . Proceedings of the National Academy of Sciences of the United States of America . 92 . 17 . 7834–8 . Aug 1995 . 7644501 . 41240 . 10.1073/pnas.92.17.7834 . 1995PNAS...92.7834S . free .
  23. Gillissen B, Essmann F, Graupner V, Stärck L, Radetzki S, Dörken B, Schulze-Osthoff K, Daniel PT . Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway . The EMBO Journal . 22 . 14 . 3580–90 . Jul 2003 . 12853473 . 165613 . 10.1093/emboj/cdg343 .
  24. Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC . Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function . Molecular Cell . 17 . 3 . 393–403 . Feb 2005 . 15694340 . 10.1016/j.molcel.2004.12.030 . free .
  25. Jiang A, Clark EA . Involvement of Bik, a proapoptotic member of the Bcl-2 family, in surface IgM-mediated B cell apoptosis . Journal of Immunology . 166 . 10 . 6025–33 . May 2001 . 11342619 . 10.4049/jimmunol.166.10.6025 . free .
  26. Lin B, Kolluri SK, Lin F, Liu W, Han YH, Cao X, Dawson MI, Reed JC, Zhang XK . Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3 . Cell . 116 . 4 . 527–40 . Feb 2004 . 14980220 . 10.1016/S0092-8674(04)00162-X . 17808479 . free .
  27. Inohara N, Ding L, Chen S, Núñez G . harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L) . The EMBO Journal . 16 . 7 . 1686–94 . Apr 1997 . 9130713 . 1169772 . 10.1093/emboj/16.7.1686 .
  28. Imaizumi K, Morihara T, Mori Y, Katayama T, Tsuda M, Furuyama T, Wanaka A, Takeda M, Tohyama M . The cell death-promoting gene DP5, which interacts with the BCL2 family, is induced during neuronal apoptosis following exposure to amyloid beta protein . The Journal of Biological Chemistry . 274 . 12 . 7975–81 . Mar 1999 . 10075695 . 10.1074/jbc.274.12.7975 . free .
  29. Rebollo A, Ayllón V, Fleischer A, Martínez CA, Zaballos A . The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis . Journal of Immunology . 167 . 11 . 6366–73 . Dec 2001 . 11714801 . 10.4049/jimmunol.167.11.6366 . free .
  30. Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N . Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis . Science . 288 . 5468 . 1053–8 . May 2000 . 10807576 . 10.1126/science.288.5468.1053 . 2000Sci...288.1053O .
  31. Ayllón V, Cayla X, García A, Fleischer A, Rebollo A . The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad . European Journal of Immunology . 32 . 7 . 1847–55 . Jul 2002 . 12115603 . 10.1002/1521-4141(200207)32:7<1847::AID-IMMU1847>3.0.CO;2-7 . free .
  32. Passer BJ, Pellegrini L, Vito P, Ganjei JK, D'Adamio L . Interaction of Alzheimer's presenilin-1 and presenilin-2 with Bcl-X(L). A potential role in modulating the threshold of cell death . The Journal of Biological Chemistry . 274 . 34 . 24007–13 . Aug 1999 . 10446169 . 10.1074/jbc.274.34.24007 . free .
  33. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
  34. Komatsu K, Miyashita T, Hang H, Hopkins KM, Zheng W, Cuddeback S, Yamada M, Lieberman HB, Wang HG . Human homologue of S. pombe Rad9 interacts with BCL-2/BCL-xL and promotes apoptosis . Nature Cell Biology . 2 . 1 . 1–6 . Jan 2000 . 10620799 . 10.1038/71316 . 52847351 .
  35. Tagami S, Eguchi Y, Kinoshita M, Takeda M, Tsujimoto Y . A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity . Oncogene . 19 . 50 . 5736–46 . Nov 2000 . 11126360 . 10.1038/sj.onc.1203948 . free .
  36. Weng C, Li Y, Xu D, Shi Y, Tang H . Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells . The Journal of Biological Chemistry . 280 . 11 . 10491–500 . Mar 2005 . 15637055 . 10.1074/jbc.M412819200 . free .
  37. Shi Y, Chen J, Weng C, Chen R, Zheng Y, Chen Q, Tang H . Identification of the protein-protein contact site and interaction mode of human VDAC1 with Bcl-2 family proteins . Biochemical and Biophysical Research Communications . 305 . 4 . 989–96 . Jun 2003 . 12767928 . 10.1016/S0006-291X(03)00871-4 .
  38. Shimizu S, Konishi A, Kodama T, Tsujimoto Y . BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death . Proceedings of the National Academy of Sciences of the United States of America . 97 . 7 . 3100–5 . Mar 2000 . 10737788 . 16199 . 10.1073/pnas.97.7.3100 . 2000PNAS...97.3100S . free .
  39. Shimizu S, Narita M, Tsujimoto Y . Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC . Nature . 399 . 6735 . 483–7 . Jun 1999 . 10365962 . 10.1038/20959 . 1999Natur.399..483S . 4423304 .

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Bcl-2-like protein 1".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.