BCCIP explained

BRCA2 and CDKN1A-interacting protein is a protein that is encoded by the BCCIP gene in humans.[1] [2] [3]

This gene product was isolated based on its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. Several transcript variants encoding different isoforms have been described for this gene.

Interactions

BCCIP has been shown to interact with BRCA2, P21, and PTPmu (PTPRM)[4]

Further reading

Notes and References

  1. Liu J, Yuan Y, Huan J, Shen Z . Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2 . Oncogene . 20 . 3 . 336–45 . Apr 2001 . 11313963 . 10.1038/sj.onc.1204098 . free .
  2. Ono T, Kitaura H, Ugai H, Murata T, Yokoyama KK, Iguchi-Ariga SM, Ariga H . TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase . J Biol Chem . 275 . 40 . 31145–54 . Oct 2000 . 10878006 . 10.1074/jbc.M003031200 . free .
  3. Web site: Entrez Gene: BCCIP BRCA2 and CDKN1A interacting protein.
  4. Phillips-Mason PJ, Mourton T, Major DL, Brady-Kalnay SM. BCCIP associates with the receptor protein tyrosine phosphatase PTPmu. . J Cell Biochem . 2008 . 105 . 4 . 1059–72 . 18773424 . 10.1002/jcb.21907 . 2758318 .