BCAS3 explained

Breast carcinoma amplified sequence 3, also known as BCAS3, is a protein which in humans is encoded by the BCAS3 gene.^{[1] [2]} BCAS3 is a gene that is amplified and overexpressed in breast cancer cells.^[2]

Function

The BCAS3 gene is regulated by estrogen receptor alpha (ER-α).^[3] The PELP1 protein acts as a transcriptional coactivator of estrogen receptor induced BCAS3 gene expression. In addition BCAS3 possesses histone acetyltransferase activity and itself appears to act as a coactivator of ER-α.^[4] Furthermore, BCAS3 requires PELP1 to function as a coactivator in ER-α. Hence BCAS3 apparently is involved in a positive feedback loop leading to ER-α mediated signal amplification.^[4]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Bärlund M, Monni O, Weaver JD . Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer . Genes Chromosomes Cancer . 35 . 4 . 311–7 . 2003 . 12378525 . 10.1002/gcc.10121 . 9759638 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . etal.
• Gururaj AE, Singh RR, Rayala SK . MTA1, a transcriptional activator of breast cancer amplified sequence 3 . Proc. Natl. Acad. Sci. U.S.A. . 103 . 17 . 6670–5 . 2006 . 16617102 . 10.1073/pnas.0601989103 . 1458939 . 2006PNAS..103.6670G . etal. free .
• Gururaj AE, Holm C, Landberg G, Kumar R . Breast cancer-amplified sequence 3, a target of metastasis-associated protein 1, contributes to tamoxifen resistance in premenopausal patients with breast cancer . Cell Cycle . 5 . 13 . 1407–10 . 2006 . 16855396 . 10.4161/cc.5.13.2924. free .
• Gururaj AE, Peng S, Vadlamudi RK, Kumar R . Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1) . Mol. Endocrinol. . 21 . 8 . 1847–60 . 2007 . 17505058 . 10.1210/me.2006-0514 . free .

Notes and References

1. Web site: Entrez Gene: BCAS3 breast carcinoma amplified sequence 3.
2. Bärlund M, Monni O, Weaver JD, Kauraniemi P, Sauter G, Heiskanen M, Kallioniemi OP, Kallioniemi A . Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer . Genes Chromosomes Cancer . 35 . 4 . 311–7 . December 2002 . 12378525 . 10.1002/gcc.10121 . 9759638 .
3. Gururaj AE, Singh RR, Rayala SK, Holm C, den Hollander P, Zhang H, Balasenthil S, Talukder AH, Landberg G, Kumar R . MTA1, a transcriptional activator of breast cancer amplified sequence 3 . Proc. Natl. Acad. Sci. U.S.A. . 103 . 17 . 6670–5 . April 2006 . 16617102 . 1458939 . 10.1073/pnas.0601989103 . 2006PNAS..103.6670G . free .
4. Gururaj AE, Peng S, Vadlamudi RK, Kumar R . Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1) . Mol. Endocrinol. . 21. 8 . 1847–60 . August 2007 . 17505058 . 10.1210/me.2006-0514 . free .