BCAS1 explained

Breast carcinoma-amplified sequence 1 is a protein that in humans is encoded by the BCAS1 gene.^{[1] [2]}

Breast carcinoma amplified sequence 1 (BCAS1) was isolated from a region at 20q13 which is amplified in a variety of tumor types and associated with more aggressive tumor phenotypes. Among the genes identified from this region, BCAS1 was found to be highly expressed in three amplified breast cancer cell lines and in one breast tumor without amplification at 20q13.2. However, the BCAS1 gene is not in the common region of maximal amplification and its expression was not detected in the breast cancer cell line MCF7, in which this region is highly amplified. Although not consistently expressed, BCAS1 is a candidate oncogene. It is predicted to encode a protein of 584 amino acids with no significant homology to other proteins.^[2]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Tanner MM, Tirkkonen M, Kallioniemi A . Independent amplification and frequent co-amplification of three nonsyntenic regions on the long arm of chromosome 20 in human breast cancer . Cancer Res. . 56 . 15 . 3441–5 . 1996 . 8758909 . etal.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Correa RG, de Carvalho AF, Pinheiro NA . NABC1 (BCAS1): alternative splicing and downregulation in colorectal tumors . Genomics . 65 . 3 . 299–302 . 2000 . 10857754 . 10.1006/geno.2000.6172 . etal.
• Lo KW, Naisbitt S, Fan JS . The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif . J. Biol. Chem. . 276 . 17 . 14059–66 . 2001 . 11148209 . 10.1074/jbc.M010320200 . etal. free .
• Deloukas P, Matthews LH, Ashurst J . The DNA sequence and comparative analysis of human chromosome 20 . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . 2001Natur.414..865D . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Beardsley DI, Kowbel D, Lataxes TA . Characterization of the novel amplified in breast cancer-1 (NABC1) gene product . Exp. Cell Res. . 290 . 2 . 402–13 . 2003 . 14567997 . 10.1016/S0014-4827(03)00353-7 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Ewing RM, Chu P, Elisma F . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . etal.

Notes and References

1. Collins C, Rommens JM, Kowbel D, Godfrey T, Tanner M, Hwang SI, Polikoff D, Nonet G, Cochran J, Myambo K, Jay KE, Froula J, Cloutier T, Kuo WL, Yaswen P, Dairkee S, Giovanola J, Hutchinson GB, Isola J, Kallioniemi OP, Palazzolo M, Martin C, Ericsson C, Pinkel D, Albertson D, Li WB, Gray JW . Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma . Proc Natl Acad Sci U S A . 95 . 15 . 8703–8 . Aug 1998 . 9671742 . 21140 . 10.1073/pnas.95.15.8703 . 1998PNAS...95.8703C . free .
2. Web site: Entrez Gene: BCAS1 breast carcinoma amplified sequence 1.