Brevican Explained

Brevican core protein is a protein that in humans is encoded by the BCAN gene.^{[1] [2] [3]} Brevican is a member of the lectican protein family.

Brevican is localised to the surface of neurons in the brain.^[4] In melanocytic cells, BCAN gene expression may be regulated by MITF.^[5]

Further reading

• Hu B, Kong LL, Matthews RT, Viapiano MS . The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility . The Journal of Biological Chemistry . 283 . 36 . 24848–59 . Sep 2008 . 18611854 . 3259830 . 10.1074/jbc.M801433200 . free .
• Seidenbecher CI, Richter K, Rauch U, Fässler R, Garner CC, Gundelfinger ED . Brevican, a chondroitin sulfate proteoglycan of rat brain, occurs as secreted and cell surface glycosylphosphatidylinositol-anchored isoforms . The Journal of Biological Chemistry . 270 . 45 . 27206–12 . Nov 1995 . 7592978 . 10.1074/jbc.270.45.27206 . free .
• Aspberg A, Miura R, Bourdoulous S, Shimonaka M, Heinegârd D, Schachner M, Ruoslahti E, Yamaguchi Y . The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety . Proceedings of the National Academy of Sciences of the United States of America . 94 . 19 . 10116–21 . Sep 1997 . 9294172 . 23322 . 10.1073/pnas.94.19.10116 . 1997PNAS...9410116A . free .
• Nakamura H, Fujii Y, Inoki I, Sugimoto K, Tanzawa K, Matsuki H, Miura R, Yamaguchi Y, Okada Y . Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites . The Journal of Biological Chemistry . 275 . 49 . 38885–90 . Dec 2000 . 10986281 . 10.1074/jbc.M003875200 . free .
• Olin AI, Mörgelin M, Sasaki T, Timpl R, Heinegård D, Aspberg A . The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding . The Journal of Biological Chemistry . 276 . 2 . 1253–61 . Jan 2001 . 11038354 . 10.1074/jbc.M006783200 . free .
• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment . Genome Research . 13 . 10 . 2265–70 . Oct 2003 . 12975309 . 403697 . 10.1101/gr.1293003 .
• Xu XM, Chen Y, Chen J, Yang S, Gao F, Underhill CB, Creswell K, Zhang L . A peptide with three hyaluronan binding motifs inhibits tumor growth and induces apoptosis . Cancer Research . 63 . 18 . 5685–90 . Sep 2003 . 14522884 .
• Bekku Y, Su WD, Hirakawa S, Fässler R, Ohtsuka A, Kang JS, Sanders J, Murakami T, Ninomiya Y, Oohashi T . Molecular cloning of Bral2, a novel brain-specific link protein, and immunohistochemical colocalization with brevican in perineuronal nets . Molecular and Cellular Neurosciences . 24 . 1 . 148–59 . Sep 2003 . 14550776 . 10.1016/S1044-7431(03)00133-7 . 25762224 .
• Dong Y, Han X, Xue Y, Dong B, Guo X, Hu G, Zhu C, Lu Y . Secreted brevican mRNA is expressed in the adult rat pituitary . Biochemical and Biophysical Research Communications . 314 . 3 . 745–8 . Feb 2004 . 14741698 . 10.1016/j.bbrc.2003.12.151 .
• Viapiano MS, Bi WL, Piepmeier J, Hockfield S, Matthews RT . Novel tumor-specific isoforms of BEHAB/brevican identified in human malignant gliomas . Cancer Research . 65 . 15 . 6726–33 . Aug 2005 . 16061654 . 10.1158/0008-5472.CAN-05-0585 . free .
• Nakada M, Miyamori H, Kita D, Takahashi T, Yamashita J, Sato H, Miura R, Yamaguchi Y, Okada Y . Human glioblastomas overexpress ADAMTS-5 that degrades brevican . Acta Neuropathologica . 110 . 3 . 239–46 . Sep 2005 . 16133547 . 10.1007/s00401-005-1032-6 . 25744956 .
• Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Gary SC, Zerillo CA, Chiang VL, Gaw JU, Gray G, Hockfield S . cDNA cloning, chromosomal localization, and expression analysis of human BEHAB/brevican, a brain specific proteoglycan regulated during cortical development and in glioma . Gene . 256 . 1–2 . 139–47 . Oct 2000 . 11054543 . 10.1016/S0378-1119(00)00362-0 . free .
2. Nomoto H, Oohashi T, Hirakawa S, Ueki Y, Ohtsuki H, Ninomiya Y . Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23 . Acta Medica Okayama . 56 . 1 . 25–9 . Feb 2002 . 11873941 .
3. Web site: Entrez Gene: BCAN brevican.
4. Frischknecht R, Seidenbecher CI . Brevican: a key proteoglycan in the perisynaptic extracellular matrix of the brain . The International Journal of Biochemistry & Cell Biology . 44 . 7 . 1051–4 . Jul 2012 . 22537913 . 10.1016/j.biocel.2012.03.022 .
5. Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E . Novel MITF targets identified using a two-step DNA microarray strategy . Pigment Cell & Melanoma Research . 21 . 6 . 665–76 . Dec 2008 . 19067971 . 10.1111/j.1755-148X.2008.00505.x . free .