Basal cell adhesion molecule explained

Basal cell adhesion molecule, also known as Lutheran antigen, is a plasma membrane glycoprotein that in humans is encoded by the BCAM gene.^[1] BCAM has also recently been designated CD239 (cluster of differentiation 239).

Function

Lutheran blood group glycoprotein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five, N-terminus, extracellular immunoglobulin domains, a single transmembrane domain, and a short, C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Two transcript variants encoding different isoforms have been found for this gene.

Interactions

BCAM has been shown to interact with Laminin, alpha 5. BCAM has also been shown to promote the metastasis of ovarian cancer.^{[2] [3] [4]}

Further reading

• Eyler CE, Telen MJ . The Lutheran glycoprotein: a multifunctional adhesion receptor. . Transfusion . 46 . 4 . 668–77 . 2006 . 16584446 . 10.1111/j.1537-2995.2006.00779.x . 37594599 .
• Lewis M, Kaita H, Coghlan G . The chromosome 19 linkage group LDLR, C3, LW, APOC2, LU, SE in man. . Ann. Hum. Genet. . 52 . Pt 2 . 137–44 . 1989 . 2907851 . 10.1111/j.1469-1809.1988.tb01089.x . 26927877 . etal.
• Parsons SF, Mallinson G, Holmes CH . The Lutheran blood group glycoprotein, another member of the immunoglobulin superfamily, is widely expressed in human tissues and is developmentally regulated in human liver. . Proc. Natl. Acad. Sci. U.S.A. . 92 . 12 . 5496–500 . 1995 . 7777537 . 10.1073/pnas.92.12.5496 . 41722 . 1995PNAS...92.5496P . etal. free .
• Campbell IG, Foulkes WD, Senger G . Molecular cloning of the B-CAM cell surface glycoprotein of epithelial cancers: a novel member of the immunoglobulin superfamily. . Cancer Res. . 54 . 22 . 5761–5 . 1994 . 7954395 . etal.
• Rahuel C, Le Van Kim C, Mattei MG . A unique gene encodes spliceoforms of the B-cell adhesion molecule cell surface glycoprotein of epithelial cancer and of the Lutheran blood group glycoprotein. . Blood . 88 . 5 . 1865–72 . 1996 . 8781446 . 10.1182/blood.V88.5.1865.1865. etal. free .
• Parsons SF, Mallinson G, Daniels GL . Use of domain-deletion mutants to locate Lutheran blood group antigens to each of the five immunoglobulin superfamily domains of the Lutheran glycoprotein: elucidation of the molecular basis of the Lu(a)/Lu(b) and the Au(a)/Au(b) polymorphisms. . Blood . 89 . 11 . 4219–25 . 1997 . 9166867 . 10.1182/blood.V89.11.4219. etal. free .
• El Nemer W, Rahuel C, Colin Y . Organization of the human LU gene and molecular basis of the Lu(a)/Lu(b) blood group polymorphism. . Blood . 89 . 12 . 4608–16 . 1997 . 9192786 . 10.1182/blood.V89.12.4608. etal. free .
• Parsons SF, Lee G, Spring FA . Lutheran blood group glycoprotein and its newly characterized mouse homologue specifically bind alpha5 chain-containing human laminin with high affinity. . Blood . 97 . 1 . 312–20 . 2001 . 11133776 . 10.1182/blood.V97.1.312 . 10715366 . etal. free .
• El Nemer W, Gane P, Colin Y . Characterization of the laminin binding domains of the Lutheran blood group glycoprotein. . J. Biol. Chem. . 276 . 26 . 23757–62 . 2001 . 11319237 . 10.1074/jbc.M102978200 . etal. free .
• Kikkawa Y, Moulson CL, Virtanen I, Miner JH . Identification of the binding site for the Lutheran blood group glycoprotein on laminin alpha 5 through expression of chimeric laminin chains in vivo. . J. Biol. Chem. . 277 . 47 . 44864–9 . 2003 . 12244066 . 10.1074/jbc.M208731200 . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal . 2002PNAS...9916899M. free .
• Shin BK, Wang H, Yim AM . Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function. . J. Biol. Chem. . 278 . 9 . 7607–16 . 2003 . 12493773 . 10.1074/jbc.M210455200 . etal. free .
• Zhang H, Li XJ, Martin DB, Aebersold R . Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. . Nat. Biotechnol. . 21 . 6 . 660–6 . 2003 . 12754519 . 10.1038/nbt827 . 581283 .
• Crew VK, Green C, Daniels G . Molecular bases of the antigens of the Lutheran blood group system. . Transfusion . 43 . 12 . 1729–37 . 2004 . 14641871 . 10.1111/j.0041-1132.2003.00600.x . 23121476 .
• Zen Q, Batchvarova M, Twyman CA . B-CAM/LU expression and the role of B-CAM/LU activation in binding of low- and high-density red cells to laminin in sickle cell disease. . Am. J. Hematol. . 75 . 2 . 63–72 . 2004 . 14755370 . 10.1002/ajh.10442 . 25313713 . etal. free .
• Kroviarski Y, El Nemer W, Gane P . Direct interaction between the Lu/B-CAM adhesion glycoproteins and erythroid spectrin. . Br. J. Haematol. . 126 . 2 . 255–64 . 2004 . 15238148 . 10.1111/j.1365-2141.2004.05010.x . 27161744 . etal. free .
• Drewniok C, Wienrich BG, Schön M . Molecular interactions of B-CAM (basal-cell adhesion molecule) and laminin in epithelial skin cancer. . Arch. Dermatol. Res. . 296 . 2 . 59–66 . 2005 . 15278364 . 10.1007/s00403-004-0481-4 . 20724995 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Cheng J, Kapranov P, Drenkow J . Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution. . Science . 308 . 5725 . 1149–54 . 2005 . 15790807 . 10.1126/science.1108625 . 2005Sci...308.1149C . 13047538 . etal.
• Sivakumar S, Lieber S, Librizzi D . Basal cell adhesion molecule promotes metastasis-associated processes in ovarian cancer. . Clin Transl Med. 13 . 1 . 2023 . e1176 . 36647260 . 10.1002/ctm2.1176 . 9842900 . etal. free .
• Vainionpää N, Kikkawa Y, Lounatmaa K . Laminin-10 and Lutheran blood group glycoproteins in adhesion of human endothelial cells. . Am. J. Physiol., Cell Physiol. . 290 . 3 . C764–75 . 2006 . 16236823 . 10.1152/ajpcell.00285.2005 . etal.

Notes and References

1. Web site: Entrez Gene: BCAM basal cell adhesion molecule (Lutheran blood group).
2. Parsons SF, Lee G, Spring FA, Willig TN, Peters LL, Gimm JA, Tanner MJ, Mohandas N, Anstee DJ, Chasis JA . Lutheran blood group glycoprotein and its newly characterized mouse homologue specifically bind alpha5 chain-containing human laminin with high affinity . Blood . 97 . 1 . 312–20 . 2001 . 11133776 . 10.1182/blood.v97.1.312. 10715366 . free .
3. Kikkawa Y, Moulson CL, Virtanen I, Miner JH . Identification of the binding site for the Lutheran blood group glycoprotein on laminin alpha 5 through expression of chimeric laminin chains in vivo . J. Biol. Chem. . 277 . 47 . 44864–9 . 2002 . 12244066 . 10.1074/jbc.M208731200 . free .
4. Sivakumar S, Lieber S, Librizzi D. Basal cell adhesion molecule promotes metastasis-associated processes in ovarian cancer . Clin Transl Med . 13 . 1. 2023 . e1176 . 36647260 . 10.1002/ctm2.1176 . 9842900 . free.