BAZ1A explained

Bromodomain adjacent to zinc finger domain protein 1A is a protein that in humans is encoded by the BAZ1A gene.^{[1] [2]}

Structure

The protein encoded by this gene belongs to a family of proteins which includes BAZ1B, BAZ2A, and BAZ2B. All family members contain the following domains and structural motifs:^[1]

• N-terminus – PHD finger (C4HC3 zinc finger)
• WAKZ motif
• LH (leucine-rich helical domain) motif
• C-terminus – bromodomain

Function

BAZ1A along with SMARCA5, POLE3, and CHRAC1 comprise the WCRF/CHRAC ATP-dependent chromatin-remodeling complex.^{[3] [4]}

The purified CHRAC complex can mobilize nucleosomes into a regularly spaced nucleosomal array, and the spacing activity is ATP-dependent.^[4] Furthermore, the BAZ1A-SMARCA5 complex enables DNA replication through highly condensed regions of chromatin.^[5]

Interactions

BAZ1A has been shown to interact with SMARCA5^{[6] [7] [8]} and SATB1.^[7]

Notes and References

1. Jones MH, Hamana N, Nezu J, Shimane M . A novel family of bromodomain genes . Genomics . 63 . 1 . 40–5 . Apr 2000 . 10662543 . 10.1006/geno.1999.6071 .
2. Web site: Entrez Gene: BAZ1A bromodomain adjacent to zinc finger domain, 1A.
3. Bochar DA, Savard J, Wang W, Lafleur DW, Moore P, Côté J, Shiekhattar R . A family of chromatin remodeling factors related to Williams syndrome transcription factor . Proc. Natl. Acad. Sci. U.S.A. . 97 . 3 . 1038–43 . February 2000 . 10655480 . 15513 . 10.1073/pnas.97.3.1038 . 2000PNAS...97.1038B . free .
4. Poot RA, Dellaire G, Hülsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD . HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins . EMBO J. . 19 . 13 . 3377–87 . July 2000 . 10880450 . 313940 . 10.1093/emboj/19.13.3377 .
5. Collins N, Poot RA, Kukimoto I, García-Jiménez C, Dellaire G, Varga-Weisz PD . An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin . Nat. Genet. . 32 . 4 . 627–32 . December 2002 . 12434153 . 10.1038/ng1046 . 22545162 .
6. Bozhenok . Ludmila . Wade Paul A . Varga-Weisz Patrick . May 2002 . WSTF–ISWI chromatin remodeling complex targets heterochromatic replication foci . EMBO J. . 21 . 9 . 2231–41 . England. 0261-4189. 11980720 . 10.1093/emboj/21.9.2231 . 125993 .
7. Yasui . Dag . Miyano Masaru . Cai Shutao . Varga-Weisz Patrick . Kohwi-Shigematsu Terumi . Oct 2002 . SATB1 targets chromatin remodelling to regulate genes over long distances . . 419 . 6907 . 641–5 . England. 0028-0836. 12374985 . 10.1038/nature01084 . 2002Natur.419..641Y . 25822700 .
8. Hakimi . Mohamed-Ali . Bochar Daniel A . Schmiesing John A . Dong Yuanshu . Barak Orr G . Speicher David W . Yokomori Kyoko . Shiekhattar Ramin . Aug 2002 . A chromatin remodelling complex that loads cohesin onto human chromosomes . . 418 . 6901 . 994–8 . England. 0028-0836. 12198550 . 10.1038/nature01024 . 2002Natur.418..994H . 4344470 .