BAY 60–6583 explained

BAY 60–6583 is a selective adenosine A2B receptor agonist.[1] It has been shown to provide protection from ischemia (lack of oxygen due to blocked blood supply) in both the heart and kidney of test animals,[2] [3] and has also been shown to be beneficial in treatment of acute lung and brain injury,[4] [5] as well as claimed anti-aging and anti-obesity effects,[6] showing a range of potential applications for selective A2B agonists.

Notes and References

  1. Baraldi PG, Tabrizi MA, Fruttarolo F, Romagnoli R, Preti D . Recent improvements in the development of A(2B) adenosine receptor agonists . Purinergic Signalling . 4 . 4 . 287–303 . December 2008 . 18443746 . 2583210. 10.1007/s11302-008-9097-z . free .
  2. Eckle T, Krahn T, Grenz A, Köhler D, Mittelbronn M, Ledent C, Jacobson MA, Osswald H, Thompson LF, Unertl K, Eltzschig HK . 6 . Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors . Circulation . 115 . 12 . 1581–90 . March 2007 . 17353435 . 10.1161/CIRCULATIONAHA.106.669697 . free .
  3. Grenz A, Osswald H, Eckle T, Yang D, Zhang H, Tran ZV, Klingel K, Ravid K, Eltzschig HK . 6 . The reno-vascular A2B adenosine receptor protects the kidney from ischemia . PLOS Medicine . 5 . 6 . e137 . June 2008 . 18578565 . 2504049. 10.1371/journal.pmed.0050137 . free .
  4. Eckle T, Grenz A, Laucher S, Eltzschig HK . A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice . The Journal of Clinical Investigation . 118 . 10 . 3301–15 . October 2008 . 18787641 . 10.1172/JCI34203 . free . 2532979 .
  5. Li Q, Han X, Lan X, Hong X, Li Q, Gao Y, Luo T, Yang Q, Koehler RC, Zhai Y, Zhou J, Wang J . 6 . Inhibition of tPA-induced hemorrhagic transformation involves adenosine A2b receptor activation after cerebral ischemia . Neurobiology of Disease . 108 . 173–182 . December 2017 . 28830843 . 10.1016/j.nbd.2017.08.011 . 5675803 .
  6. Gnad T, Navarro G, Lahesmaa M, Reverte-Salisa L, Copperi F, Cordomi A, Naumann J, Hochhäuser A, Haufs-Brusberg S, Wenzel D, Suhr F, Jespersen NZ, Scheele C, Tsvilovskyy V, Brinkmann C, Rittweger J, Dani C, Kranz M, Deuther-Conrad W, Eltzschig HK, Niemi T, Taittonen M, Brust P, Nuutila P, Pardo L, Fleischmann BK, Blüher M, Franco R, Bloch W, Virtanen KA, Pfeifer A . 6 . Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity . Cell Metabolism . 32 . 1 . 56–70.e7 . July 2020 . 32589947 . 10.1016/j.cmet.2020.06.006. 7437516 .

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