BAT1 explained

Spliceosome RNA helicase BAT1 is an enzyme that in humans is encoded by the BAT1 gene.^{[1] [2] [3]}

This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and also plays an important role in mRNA export from the nucleus to the cytoplasm. A cluster of genes, BAT1-BAT5, is localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants encoding the same protein have been described.

External links

• • PDBe-KB provides an overview of all the structure information available in the PDB for Human Spliceosome RNA helicase DDX39B (BAT1)

Further reading

• Spies T, Blanck G, Bresnahan M . A new cluster of genes within the human major histocompatibility complex. . Science . 243 . 4888 . 214–7 . 1989 . 2911734 . 10.1126/science.2911734 . 1989Sci...243..214S . etal.
• Cross SH, Charlton JA, Nan X, Bird AP . Purification of CpG islands using a methylated DNA binding column. . Nat. Genet. . 6 . 3 . 236–44 . 1994 . 8012384 . 10.1038/ng0394-236 . 12847618 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Fleckner J, Zhang M, Valcárcel J, Green MR . U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction. . Genes Dev. . 11 . 14 . 1864–72 . 1997 . 9242493 . 10.1101/gad.11.14.1864 . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Allcock RJ, Price P, Gaudieri S . Characterisation of the human central MHC gene, BAT1: genomic structure and expression. . Exp. Clin. Immunogenet. . 16 . 2 . 98–106 . 1999 . 10343160 . 10.1159/000019100 . 22003689 . etal.
• Ota M, Katsuyama Y, Kimura A . A second susceptibility gene for developing rheumatoid arthritis in the human MHC is localized within a 70-kb interval telomeric of the TNF genes in the HLA class III region. . Genomics . 71 . 3 . 263–70 . 2001 . 11170743 . 10.1006/geno.2000.6371 . etal.
• Allcock RJ, Williams JH, Price P . The central MHC gene, BAT1, may encode a protein that down-regulates cytokine production. . Genes Cells . 6 . 5 . 487–94 . 2001 . 11380625 . 10.1046/j.1365-2443.2001.00435.x . 10605522 .
• Luo ML, Zhou Z, Magni K . Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly. . Nature . 413 . 6856 . 644–7 . 2001 . 11675789 . 10.1038/35098106 . 2001Natur.413..644L . 4395388 . etal.
• Andersen JS, Lyon CE, Fox AH . Directed proteomic analysis of the human nucleolus. . Curr. Biol. . 12 . 1 . 1–11 . 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . 14132033 . etal. free . 2002CBio...12....1A .
• Strässer K, Masuda S, Mason P . TREX is a conserved complex coupling transcription with messenger RNA export. . Nature . 417 . 6886 . 304–8 . 2002 . 11979277 . 10.1038/nature746 . 2002Natur.417..304S . 1112194 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• McCracken S, Longman D, Johnstone IL . An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation. . J. Biol. Chem. . 278 . 45 . 44153–60 . 2004 . 12944400 . 10.1074/jbc.M306856200 . etal. free .
• Reuter TY, Medhurst AL, Waisfisz Q . Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport. . Exp. Cell Res. . 289 . 2 . 211–21 . 2003 . 14499622 . 10.1016/S0014-4827(03)00261-1 . etal.
• Li J, Hawkins IC, Harvey CD . Regulation of alternative splicing by SRrp86 and its interacting proteins. . Mol. Cell. Biol. . 23 . 21 . 7437–47 . 2003 . 14559993 . 10.1128/MCB.23.21.7437-7447.2003 . 207616 . etal.
• Mungall AJ, Palmer SA, Sims SK . The DNA sequence and analysis of human chromosome 6. . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . etal. free .
• Lehner B, Semple JI, Brown SE . Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. . Genomics . 83 . 1 . 153–67 . 2004 . 14667819 . 10.1016/S0888-7543(03)00235-0 . etal.
• Price P, Wong AM, Williamson D . Polymorphisms at positions -22 and -348 in the promoter of the BAT1 gene affect transcription and the binding of nuclear factors. . Hum. Mol. Genet. . 13 . 9 . 967–74 . 2004 . 15028669 . 10.1093/hmg/ddh113 . etal. free .

Notes and References

1. Peelman LJ, Chardon P, Nunes M, Renard C, Geffrotin C, Vaiman M, Van Zeveren A, Coppieters W, van de Weghe A, Bouquet Y . The BAT1 gene in the MHC encodes an evolutionarily conserved putative nuclear RNA helicase of the DEAD family . Genomics . 26 . 2 . 210–8 . Aug 1995 . 7601445 . 10.1016/0888-7543(95)80203-X . etal.
2. Spies T, Bresnahan M, Strominger JL . Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B . Proc Natl Acad Sci U S A . 86 . 22 . 8955–8 . Dec 1989 . 2813433 . 298409 . 10.1073/pnas.86.22.8955 . 1989PNAS...86.8955S . free .
3. Web site: Entrez Gene: BAT1 HLA-B associated transcript 1.