BASP1 explained

Brain acid soluble protein 1 is a protein that in humans is encoded by the BASP1 gene.^{[1] [2] [3]}

This gene encodes a membrane bound protein with several transient phosphorylation sites and PEST motifs. Conservation of proteins with PEST sequences among different species supports their functional significance. PEST sequences typically occur in proteins with high turnover rates. Immunological characteristics of this protein are species specific. This protein also undergoes N-terminal myristoylation.

Further reading

• Olsen JV, Blagoev B, Gnad F . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Carpenter B, Hill KJ, Charalambous M . BASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1. . Mol. Cell. Biol. . 24 . 2 . 537–49 . 2004 . 14701728 . 10.1128/MCB.24.2.537-549.2004 . 343806 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Fitzgibbon J, Neat MJ, Foot N . Assignment of brain acid-soluble protein 1 (BASP1) to human chromosome 5p15.1→p14, differential expression in human cancer cell lines as a result of alterations in gene dosage. . Cytogenet. Cell Genet. . 89 . 3–4 . 147–9 . 2000 . 10965107 . 10.1159/000015597 . 25329544 . etal.

Notes and References

1. Mosevitsky MI, Capony JP, ((Skladchikova GYu)), Novitskaya VA, ((Plekhanov AYu)), Zakharov VV . The BASP1 family of myristoylated proteins abundant in axonal termini. Primary structure analysis and physico-chemical properties . Biochimie . 79 . 6 . 373–84 . Nov 1997 . 9310187 . 10.1016/S0300-9084(97)80032-6 .
2. Park S, Kim YI, Kim B, Seong C, Oh Y, Baek K, Yoon J . Characterization of bovine and human cDNAs encoding NAP-22 (22 kDa neuronal tissue-enriched acidic protein) homologs . Mol Cells . 8 . 4 . 471–7 . Nov 1998 . 10.1016/S1016-8478(23)13453-4 . 9749536 . free .
3. Web site: Entrez Gene: BASP1 brain abundant, membrane attached signal protein 1.