BANP explained

Protein BANP is a protein that can be found in humans, it is encoded by the BANP gene.^{[1] [2] [3]} It is a member of the human gene family, "BEN-domain containing", which includes eight other genes: BEND2, BEND3, BEND4, BEND5, BEND6, BEND7, NACC1 (BEND8), and NACC2 (BEND9). BANP is a protein coding gene that is located in the Nucleoplasm. Its official name is BTG3 associated with nuclear protein. It plays a role in DNA binding, chromatin regulation, repressor, transcription regulation and the cell cycle process.^[4] In recombination BANP protein represses T-cell receptors to control recombination during transcription.^[5] As a tumor suppressor BANP negatively regulates p53 transcription in recombination.^[6] It can be expressed in various tissues in the body including the testis, spleen, and the placenta.^[7]

Function

This gene encodes a protein that binds to matrix attachment regions. The protein functions as a tumor suppressor and cell cycle regulator. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Further reading

• Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M . Generation and analysis of 280,000 human expressed sequence tags . Genome Research . 6 . 9 . 807–28 . Sep 1996 . 8889549 . 10.1101/gr.6.9.807 . free .
• Kaul R, Mukherjee S, Ahmed F, Bhat MK, Chhipa R, Galande S, Chattopadhyay S . Direct interaction with and activation of p53 by SMAR1 retards cell-cycle progression at G2/M phase and delays tumor growth in mice . International Journal of Cancer . 103 . 5 . 606–15 . Feb 2003 . 12494467 . 10.1002/ijc.10881 . 22386279 . free .
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation . Nature Biotechnology . 22 . 6 . 707–16 . Jun 2004 . 15146197 . 10.1038/nbt971 . 27764390 .
• Kaul-Ghanekar R, Jalota A, Pavithra L, Tucker P, Chattopadhyay S . SMAR1 and Cux/CDP modulate chromatin and act as negative regulators of the TCRbeta enhancer (Ebeta) . Nucleic Acids Research . 32 . 16 . 4862–75 . 2004 . 15371550 . 519105 . 10.1093/nar/gkh807 .
• Kaul-Ghanekar R, Majumdar S, Jalota A, Gulati N, Dubey N, Saha B, Chattopadhyay S . Abnormal V(D)J recombination of T cell receptor beta locus in SMAR1 transgenic mice . The Journal of Biological Chemistry . 280 . 10 . 9450–9 . Mar 2005 . 15623522 . 10.1074/jbc.M412206200 . free .
• Rampalli S, Pavithra L, Bhatt A, Kundu TK, Chattopadhyay S . Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex . Molecular and Cellular Biology . 25 . 19 . 8415–29 . Oct 2005 . 16166625 . 1265755 . 10.1128/MCB.25.19.8415-8429.2005 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Research . 16 . 1 . 55–65 . Jan 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .

Notes and References

1. Birot A, Duret L, Bartholin L, Santalucia B, Tigaud I, Magaud J, Rouault J . Identification and molecular analysis of BANP . Gene . 253 . 2 . 189–96 . Aug 2000 . 10940556 . 10.1016/S0378-1119(00)00244-4 .
2. Chattopadhyay S, Kaul R, Charest A, Housman D, Chen J . SMAR1, a novel, alternatively spliced gene product, binds the Scaffold/Matrix-associated region at the T cell receptor beta locus . Genomics . 68 . 1 . 93–6 . Aug 2000 . 10950932 . 10.1006/geno.2000.6279 .
3. Web site: Entrez Gene: BANP BTG3 associated nuclear protein.
4. Web site: National Center for Biotechnology Information . 2022-05-05 . www.ncbi.nlm.nih.gov . en.
5. Web site: https://www.nextprot.org/entry/NX_Q8N9N5/#! . 2022-05-05 . www.nextprot.org.
6. Web site: BANP BTG3 associated nuclear protein [Homo sapiens (human)] - Gene - NCBI ]. 2022-05-05 . www.ncbi.nlm.nih.gov.
7. Web site: BANP BTG3 associated nuclear protein [Homo sapiens (human)] - Gene - NCBI ]. 2022-05-05 . www.ncbi.nlm.nih.gov.