BANCR explained

BRAF-activated non-protein coding RNA is a noncoding RNA that in humans is encoded by the BANCR gene.^[1] Long non-coding RNAs (lncRNAs) are involved in the intricate network of cancer and contribute significantly to tumorigenesis and progression. BRAF activated non-coding RNA (BANCR), a 693-bp four-exon transcript, was first identified in 2012 as an oncogenic long non-coding RNA in BRAFV600E melanomas cells and was found to be associated with melanoma cell migration. Apart from melanoma, growing evidence has implicated BANCR in the development and progression of a variety of other human malignancies, including retinoblastoma, lung cancer, and gastric cancer, since its discovery. The pattern of expression of BANCR varies according to the kind of cancer, acting as either a tumour suppressor or an accelerator. Functional BANCR may be a useful biomarker for cancer diagnosis and prognosis assessment. BANCR-targeted therapy may also prove to be a promising new treatment option for human cancers.^[2]

Further reading

• Ross JF, Dan EW, Kun Q, Nicholas M, Joanna K, Markus K, Paul AK. BRAFV600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migration . Genome Res.. 2012 . 22 . 6 . 1006–1014 . 22581800. 10.1101/gr.140061.112 . 3371703 . free.
• Sherrill JD, Kiran KC, Blanchard C, Stucke EM, Kemme KA, Collins MH, Abonia JP, Putnam PE, Mukkada VA, Kaul A, Kocoshis SA, Kushner JP, Plassard AJ, Karns RA, Dexheimer PJ, Aronow BJ, Rothenberg ME . Analysis and expansion of the eosinophilic esophagitis transcriptome by RNA sequencing . Genes Immun. . 15 . 6 . 361–9 . 2014 . 24920534 . 4156528 . 10.1038/gene.2014.27 .
• Jiang W, Zhang D, Xu B, Wu Z, Liu S, Zhang L, Tian Y, Han X, Tian D . Long non-coding RNA BANCR promotes proliferation and migration of lung carcinoma via MAPK pathways . Biomed. Pharmacother. . 69 . 90–5 . 2015 . 25661343 . 10.1016/j.biopha.2014.11.027 .
• Su S, Gao J, Wang T, Wang J, Li H, Wang Z . Long non-coding RNA BANCR regulates growth and metastasis and is associated with poor prognosis in retinoblastoma . Tumour Biol. . 36 . 9 . 7205–11 . 2015 . 25894373 . 10.1007/s13277-015-3413-3 . 23350523 .
• Shi Y, Liu Y, Wang J, Jie D, Yun T, Li W, Yan L, Wang K, Feng J . Downregulated Long Noncoding RNA BANCR Promotes the Proliferation of Colorectal Cancer Cells via Downregualtion of p21 Expression . PLOS ONE . 10 . 4 . e0122679 . 2015 . 25928067 . 4415816 . 10.1371/journal.pone.0122679 . 2015PLoSO..1022679S . free .
• Li L, Zhang L, Zhang Y, Zhou F . Increased expression of LncRNA BANCR is associated with clinical progression and poor prognosis in gastric cancer . Biomed. Pharmacother. . 72 . 109–12 . 2015 . 26054683 . 10.1016/j.biopha.2015.04.007 .
• Zhang ZX, Liu ZQ, Jiang B, Lu XY, Ning XF, Yuan CT, Wang AL . BRAF activated non-coding RNA (BANCR) promoting gastric cancer cells proliferation via regulation of NF-κB1 . Biochem. Biophys. Res. Commun. . 465 . 2 . 225–31 . 2015 . 26248136 . 10.1016/j.bbrc.2015.07.158 .
• Li AX, Xin WQ, Ma CG . Fentanyl inhibits the invasion and migration of colorectal cancer cells via inhibiting the negative regulation of Ets-1 on BANCR . Biochem. Biophys. Res. Commun. . 465 . 3 . 594–600 . 2015 . 26296467 . 10.1016/j.bbrc.2015.08.068 .
• Liu Z, Yang T, Xu Z, Cao X . Upregulation of the long non-coding RNA BANCR correlates with tumor progression and poor prognosis in esophageal squamous cell carcinoma . Biomed. Pharmacother. . 82 . 406–12 . 2016 . 27470379 . 10.1016/j.biopha.2016.05.014 . 36882011 .

Notes and References

1. Web site: Entrez Gene: BRAF-activated non-protein coding RNA. 2017-08-01.
2. The BRAF activated non-coding RNA: A pivotal long non-coding RNA in human malignancies. 2018 . 10.1111/cpr.12449. 6528848. 29484737. Liu . Xiu-Fen . Hao . Ji-Long . Xie . Tian . Pant . Om Prakash . Lu . Cheng-Bo . Lu . Cheng-Wei . Zhou . Dan-Dan . Cell Proliferation . 51 . 4 . e12449 .