BAMBI explained

BMP and activin membrane-bound inhibitor homolog (Xenopus laevis), also known as BAMBI, is a protein which in humans is encoded by the BAMBI gene.^{[1] [2]}

Function

This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis.^[1]

Further reading

• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Lin Z, Gao C, Ning Y . The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling. . J. Biol. Chem. . 283 . 48 . 33053–8 . 2008 . 18838381 . 10.1074/jbc.M804039200 . 2662247 . etal. free .
• Sekiya T, Oda T, Matsuura K, Akiyama T . Transcriptional regulation of the TGF-beta pseudoreceptor BAMBI by TGF-beta signaling. . Biochem. Biophys. Res. Commun. . 320 . 3 . 680–4 . 2004 . 15240101 . 10.1016/j.bbrc.2004.06.017 .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Fritzmann J, Morkel M, Besser D . A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential. . Gastroenterology . 137 . 1 . 165–75 . 2009 . 19328798 . 10.1053/j.gastro.2009.03.041 . etal. free .
• Hoja MR, Wahlestedt C, Höög C . A visual intracellular classification strategy for uncharacterized human proteins. . Exp. Cell Res. . 259 . 1 . 239–46 . 2000 . 10942595 . 10.1006/excr.2000.4948 .
• Khin SS, Kitazawa R, Win N . BAMBI gene is epigenetically silenced in subset of high-grade bladder cancer. . Int. J. Cancer . 125 . 2 . 328–38 . 2009 . 19326429 . 10.1002/ijc.24318 . 32084443 . etal. free .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Wistow G, Bernstein SL, Wyatt MK . Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts. . Mol. Vis. . 8 . 196–204 . 2002 . 12107411 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Sekiya T, Adachi S, Kohu K . Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells. . J. Biol. Chem. . 279 . 8 . 6840–6 . 2004 . 14660579 . 10.1074/jbc.M310876200 . etal. free .
• Togo N, Ohwada S, Sakurai S . Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer. . World J. Gastroenterol. . 14 . 31 . 4880–8 . 2008 . 18756595 . 10.3748/wjg.14.4880. 2739940 . etal . free .
• Deloukas P, Earthrowl ME, Grafham DV . The DNA sequence and comparative analysis of human chromosome 10. . Nature . 429 . 6990 . 375–81 . 2004 . 15164054 . 10.1038/nature02462 . 2004Natur.429..375D . etal. free .
• Zhang Z, Henzel WJ . Signal peptide prediction based on analysis of experimentally verified cleavage sites. . Protein Sci. . 13 . 10 . 2819–24 . 2004 . 15340161 . 10.1110/ps.04682504 . 2286551 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Degen WG, Weterman MA, van Groningen JJ . Expression of nma, a novel gene, inversely correlates with the metastatic potential of human melanoma cell lines and xenografts. . Int. J. Cancer . 65 . 4 . 460–5 . 1996 . 8621228 . 10.1002/(SICI)1097-0215(19960208)65:4<460::AID-IJC12>3.0.CO;2-E . etal. free .

Notes and References

1. Web site: Entrez Gene: BMP and activin membrane-bound inhibitor homolog (Xenopus laevis).
2. Degen WG, Weterman MA, van Groningen JJ, Cornelissen IM, Lemmers JP, Agterbos MA, Geurts van Kessel A, Swart GW, Bloemers HP . Expression of nma, a novel gene, inversely correlates with the metastatic potential of human melanoma cell lines and xenografts . Int. J. Cancer . 65 . 4 . 460–5 . February 1996 . 8621228 . 10.1002/(SICI)1097-0215(19960208)65:4<460::AID-IJC12>3.0.CO;2-E . free .