BAG5 explained

BAG family molecular chaperone regulator 5 is a protein that in humans is encoded by the BAG5 gene.^{[1] [2] [3]}

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene.

Further reading

• Takayama S, Sato T, Krajewski S . Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity . Cell . 80 . 2 . 279–84 . 1995 . 7834747 . 10.1016/0092-8674(95)90410-7 . etal. free .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Höhfeld J, Jentsch S . GrpE-like regulation of the hsc70 chaperone by the anti-apoptotic protein BAG-1 . EMBO J. . 16 . 20 . 6209–16 . 1997 . 9321400 . 10.1093/emboj/16.20.6209 . 1326305 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Nagase T, Ishikawa K, Suyama M . Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 5 . 6 . 355–64 . 1999 . 10048485 . 10.1093/dnares/5.6.355 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.

Notes and References

1. Takayama S, Xie Z, Reed JC . An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators . J Biol Chem . 274 . 2 . 781–6 . Feb 1999 . 9873016 . 10.1074/jbc.274.2.781 . free .
2. Kalia SK, Lee S, Smith PD, Liu L, Crocker SJ, Thorarinsdottir TE, Glover JR, Fon EA, Park DS, Lozano AM . BAG5 inhibits parkin and enhances dopaminergic neuron degeneration . Neuron . 44 . 6 . 931–45 . Dec 2004 . 15603737 . 10.1016/j.neuron.2004.11.026 . free .
3. Web site: Entrez Gene: BAG5 BCL2-associated athanogene 5.