BAG2 explained

BAG family molecular chaperone regulator 2 is a protein that in humans is encoded by the BAG2 gene.^{[1] [2]}

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.^[2]

Interactions

BAG2 has been shown to interact with HSPA8.

Further reading

• Halse R, Rochford JJ, McCormack JG . Control of glycogen synthesis in cultured human muscle cells. . J. Biol. Chem. . 274 . 2 . 776–80 . 1999 . 9873015 . 10.1074/jbc.274.2.776 . etal. free .
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination. . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Wiemann S, Weil B, Wellenreuther R . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 . etal.
• Simpson JC, Wellenreuther R, Poustka A . Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. . EMBO Rep. . 1 . 3 . 287–92 . 2001 . 11256614 . 10.1093/embo-reports/kvd058 . 1083732 . etal.
• Mungall AJ, Palmer SA, Sims SK . The DNA sequence and analysis of human chromosome 6. . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Bouwmeester T, Bauch A, Ruffner H . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. . Nat. Cell Biol. . 6 . 2 . 97–105 . 2004 . 14743216 . 10.1038/ncb1086 . 11683986 . etal.
• Ueda K, Kosako H, Fukui Y, Hattori S . Proteomic identification of Bcl2-associated athanogene 2 as a novel MAPK-activated protein kinase 2 substrate. . J. Biol. Chem. . 279 . 40 . 41815–21 . 2004 . 15271996 . 10.1074/jbc.M406049200 . free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Wiemann S, Arlt D, Huber W . From ORFeome to biology: a functional genomics pipeline. . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 . etal.
• Dai Q, Qian SB, Li HH . Regulation of the cytoplasmic quality control protein degradation pathway by BAG2. . J. Biol. Chem. . 280 . 46 . 38673–81 . 2006 . 16169850 . 10.1074/jbc.M507986200 . etal. free .
• Arndt V, Daniel C, Nastainczyk W . BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP. . Mol. Biol. Cell . 16 . 12 . 5891–900 . 2006 . 16207813 . 10.1091/mbc.E05-07-0660 . 1289430 . etal.
• Mehrle A, Rosenfelder H, Schupp I . The LIFEdb database in 2006. . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 . etal.
• Ewing RM, Chu P, Elisma F . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . etal.

Notes and References

1. Takayama S, Xie Z, Reed JC . An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators . J Biol Chem . 274 . 2 . 781–6 . Feb 1999 . 9873016 . 10.1074/jbc.274.2.781 . free .
2. Web site: Entrez Gene: BAG2 BCL2-associated athanogene 2.