BAAT explained

Bile acid-CoA:amino acid N-acyltransferase is an enzyme that in humans is encoded by the BAAT gene.^[1]

The protein encoded by this gene is a liver enzyme that catalyzes the transfer of the bile acid moiety from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates which serve as detergents in the gastrointestinal tract.

Further reading

• Johnson MR, Barnes S, Kwakye JB, Diasio RB . Purification and characterization of bile acid-CoA:amino acid N-acyltransferase from human liver. . J. Biol. Chem. . 266 . 16 . 10227–33 . 1991 . 10.1016/S0021-9258(18)99213-6 . 2037576 . free .
• Falany CN, Johnson MR, Barnes S, Diasio RB . Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase. . J. Biol. Chem. . 269 . 30 . 19375–9 . 1994 . 10.1016/S0021-9258(17)32178-6 . 8034703 . free .
• Lench NJ, Telford EA, Andersen SE . An EST and STS-based YAC contig map of human chromosome 9q22.3. . Genomics . 38 . 2 . 199–205 . 1997 . 8954802 . 10.1006/geno.1996.0616 . etal.
• Solaas K, Ulvestad A, Söreide O, Kase BF . Subcellular organization of bile acid amidation in human liver: a key issue in regulating the biosynthesis of bile salts. . J. Lipid Res. . 41 . 7 . 1154–62 . 2000 . 10.1016/S0022-2275(20)32022-8 . 10884298 . free .
• Sfakianos MK, Wilson L, Sakalian M . Conserved residues in the putative catalytic triad of human bile acid Coenzyme A:amino acid N-acyltransferase. . J. Biol. Chem. . 277 . 49 . 47270–5 . 2003 . 12239217 . 10.1074/jbc.M207463200 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Carlton VE, Harris BZ, Puffenberger EG . Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT. . Nat. Genet. . 34 . 1 . 91–6 . 2003 . 12704386 . 10.1038/ng1147 . 21900697 . etal.
• Wang H, Tamba M, Kimata M . Expression of the activity of cystine/glutamate exchange transporter, system x(c)(-), by xCT and rBAT. . Biochem. Biophys. Res. Commun. . 305 . 3 . 611–8 . 2003 . 12763038 . 10.1016/S0006-291X(03)00808-8 . etal.
• O'Byrne J, Hunt MC, Rai DK . The human bile acid-CoA:amino acid N-acyltransferase functions in the conjugation of fatty acids to glycine. . J. Biol. Chem. . 278 . 36 . 34237–44 . 2003 . 12810727 . 10.1074/jbc.M300987200 . etal. free .
• Humphray SJ, Oliver K, Hunt AR . DNA sequence and analysis of human chromosome 9. . Nature . 429 . 6990 . 369–74 . 2004 . 15164053 . 10.1038/nature02465 . 2734081 . 2004Natur.429..369H . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Pellicoro A, van den Heuvel FA, Geuken M . Human and rat bile acid-CoA:amino acid N-acyltransferase are liver-specific peroxisomal enzymes: implications for intracellular bile salt transport. . Hepatology . 45 . 2 . 340–8 . 2007 . 17256745 . 10.1002/hep.21528 . 6163420 . etal. free .
• Tougou K, Fukuda T, Ito T . Genetic polymorphism of bile acid CoA: amino acid N-acyltransferase in Japanese individuals. . Drug Metab. Pharmacokinet. . 22 . 2 . 125–8 . 2007 . 17495420 . 10.2133/dmpk.22.125 . etal.

Notes and References

1. Web site: Entrez Gene: BAAT bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase).