B3GNT2 explained

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 is an enzyme that in humans is encoded by the B3GNT2 gene.^{[1] [2] [3]}

This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It prefers the substrate of lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains.^[3]

Further reading

• Amado M, Almeida R, Schwientek T, Clausen H . Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions . Biochim. Biophys. Acta . 1473 . 1 . 35–53 . 2000 . 10580128 . 10.1016/S0304-4165(99)00168-3.
• Ju T, Cummings RD . A unique molecular chaperone Cosmc required for activity of the mammalian core 1 β3-galactosyltransferase . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16613–8 . 2003 . 12464682 . 10.1073/pnas.262438199 . 139192 . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Isshiki S, Kudo T, Nishihara S . Lewis type 1 antigen synthase (beta3Gal-T5) is transcriptionally regulated by homeoproteins . J. Biol. Chem. . 278 . 38 . 36611–20 . 2003 . 12855703 . 10.1074/jbc.M302681200 . etal. free .
• Hayashi N, Nakamori S, Okami J . Association between expression levels of CA 19-9 and N-acetylglucosamine-beta;1,3-galactosyltransferase 5 gene in human pancreatic cancer tissue . Pathobiology . 71 . 1 . 26–34 . 2004 . 14555842 . 10.1159/000072959 . 11013021 . etal.
• Mare L, Trinchera M . Suppression of beta 1,3galactosyltransferase beta 3Gal-T5 in cancer cells reduces sialyl-Lewis a and enhances poly N-acetyllactosamines and sialyl-Lewis x on O-glycans . Eur. J. Biochem. . 271 . 1 . 186–194 . 2004 . 14686931 . 10.1046/j.1432-1033.2003.03919.x . 38965439 .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Hillman RT, Green RE, Brenner SE . An unappreciated role for RNA surveillance . Genome Biol. . 5 . 2 . R8 . 2005 . 14759258 . 10.1186/gb-2004-5-2-r8 . 395752 . free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Zheng H, Li Y, Ji C . Characterization of a cDNA encoding a protein with limited similarity to beta1, 3-N-acetylglucosaminyltransferase . Mol. Biol. Rep. . 31 . 3 . 171–5 . 2005 . 15560372 . 10.1023/B:MOLE.0000043552.32411.67 . 22952647 . etal.
• Liu T, Qian WJ, Gritsenko MA . Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry . J. Proteome Res. . 4 . 6 . 2070–80 . 2006 . 16335952 . 10.1021/pr0502065 . 1850943 . etal.

Notes and References

1. Zhou D, Dinter A, Gutierrez Gallego R, Kamerling JP, Vliegenthart JF, Berger EG, Hennet T . A β-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to β-1,3-galactosyltransferases . Proc Natl Acad Sci U S A . 96 . 2 . 406–11 . Mar 1999 . 9892646 . 15149 . 10.1073/pnas.96.2.406 . 1999PNAS...96..406Z . free .
2. Shiraishi N, Natsume A, Togayachi A, Endo T, Akashima T, Yamada Y, Imai N, Nakagawa S, Koizumi S, Sekine S, Narimatsu H, Sasaki K . Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family . J Biol Chem . 276 . 5 . 3498–507 . May 2001 . 11042166 . 10.1074/jbc.M004800200 . free .
3. Web site: Entrez Gene: B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2.