Azagly-nafarelin explained

Azagly-nafarelin, sold under the brand name Gonazon, is a gonadotropin-releasing hormone agonist (GnRH agonist) medication which is used in veterinary medicine in Europe.[1] [2] It is a GnRH analogue and a synthetic peptide, specifically a decapeptide.[3] The medication has been approved in Europe as a solid silicone-based matrix implant for use as a contraceptive in animals such as male dogs, cats, and others, but is no longer or was never commercially available.[4] [5] The medication has also been used to treat benign prostatic hyperplasia in animals.[6] [7] In addition to its use in mammals, azagly-nafarelin has been approved for use in aquaculture fish, specifically to control ovulation in salmonids, and was the first GnRH agonist to be available for use in fish.[8] It was introduced for use by 2005.[9]

See also

Notes and References

  1. Book: Driancourt MA, Rodes L . Male Contraception in Animal Species . Skinner MK . Encyclopedia of Reproduction. https://books.google.com/books?id=m4RlDwAAQBAJ&pg=PA554. 29 June 2018. Elsevier Science. 978-0-12-815145-7. 554–556.
  2. Book: Löscher W, Richter A, Potschka H . Pharmakotherapie bei Haus- und Nutztieren: Begründet von W. Löscher, F.R. Ungemach und R. Kroker. 3 September 2014. Enke. 978-3-8304-1251-9. 435–.
  3. Bulldan A, Shihan M, Goericke-Pesch S, Scheiner-Bobis G . Signaling events associated with gonadotropin releasing hormone-agonist-induced hormonal castration and its reversal in canines . Molecular Reproduction and Development . 83 . 12 . 1092–1101 . December 2016 . 27764533 . 10.1002/mrd.22751 . 29559009 .
  4. Rhodes L . New approaches to non-surgical sterilization for dogs and cats: Opportunities and challenges . Reproduction in Domestic Animals = Zuchthygiene . 52 . Suppl 2 . 327–331 . April 2017 . 27892642 . 10.1111/rda.12862 . free .
  5. Book: Norman ST, Collop TM . Male Animal Contraception . Chenoweth PJ, Lorton S . Animal Andrology: Theories and Applications. https://books.google.com/books?id=hv6dAwAAQBAJ&pg=PA489. 30 April 2014. CABI. 978-1-78064-316-8. 489–.
  6. Christensen BW . Veterinary Clinics of North America: Small Animal Practice . Canine Prostate Disease . 48 . 4 . 701–719 . July 2018 . 29933768 . 10.1016/j.cvsm.2018.02.012 . Elsevier Health Sciences. 978-0-323-61085-8 . 49381344 .
  7. Book: Dreier HK . Hormonbehandlung bei der Hüdin . Klinik der Reproduktionsmedizin des Hundes. https://books.google.com/books?id=550uBQAAQBAJ&pg=PA286. 6 December 2010. Schlütersche Verlagsgesellschaft mbH & Company KG. 978-3-8426-8038-8. 286–.
  8. Book: Mylonas CC, Zohar Y . Promoting oocyte maturation, ovulation, and spawning in farmed fish . Babin PJ, Cerdà J, Lubzens E . The Fish Oocyte: From Basic Studies to Biotechnological Applications. https://books.google.com/books?id=7ViiIK-lK2sC&pg=PA444. 20 August 2007. Springer Science & Business Media. 978-1-4020-6233-9. 444–.
  9. Optimization of breeding of salmonids: Gonazon, the first officially approved inducer of ovulation in the EU. World Aquaculture. 2005. Haffray P, Enright WJ, Driancourt MA, Mikolajczyk T, Rault P, Breton B . 2018-07-29. 2018-07-29. https://web.archive.org/web/20180729050116/http://agris.fao.org/agris-search/search.do?recordID=US201300988052. dead.

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