Azadipyrromethene Explained

Azadipyrromethenes (ADPM) is a class of dyes used experimentally as photosensitizers for photodynamic therapy.^{[1] [2]}

Some derivatives can usefully absorb in the near-infrared.^[3] It has also been demonstrated that supramolecular coordination of an anion can switch-off the photosensitising ability of azadipyrromethene derivatives,^[4] which could improve the selectivity of photodynamic therapy agents.

See also

• Pyrromethene

Notes and References

1. Gallagher. W M. Allen. L T. O'Shea. C. Kenna. T. Hall. M. Gorman. A. Killoran. J. O'Shea. D F. A potent nonporphyrin class of photodynamic therapeutic agent: cellular localisation, cytotoxic potential and influence of hypoxia. British Journal of Cancer. 19 April 2005. 92. 9. 1702–1710. 10.1038/sj.bjc.6602527. 15841085. 2362044.
2. Byrne. A T. O'Connor. A E. Hall. M. Murtagh. J. O'Neill. K. Curran. K M. Mongrain. K. Rousseau. J A. Lecomte. R. McGee. S. Callanan. J J. O'Shea. D F. Gallagher. W M. Vascular-targeted photodynamic therapy with BF2-chelated Tetraaryl-Azadipyrromethene agents: a multi-modality molecular imaging approach to therapeutic assessment. British Journal of Cancer. 13 October 2009. 101. 9. 1565–1573. 10.1038/sj.bjc.6605247. 19826417. 2778519.
3. McDonnell. Shane O.. O'Shea. Donal F.. Near-Infrared Sensing Properties of Dimethlyamino-Substituted BF −Azadipyrromethenes. Organic Letters. August 2006. 8. 16. 3493–3496. 10.1021/ol061171x. 16869643.
4. Taylor . Andrew J. . Beer . Paul D. . Halogen bonding aza-BODIPYs for anion sensing and anion binding-modulated singlet oxygen generation . Chemical Communications . 2024 . 10.1039/D4CC02330G. free .