| Official Name: | Ayrshire, Indiana |
| Settlement Type: | Unincorporated community |
| Pushpin Map: | Indiana#USA |
| Pushpin Label: | Ayrshire |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | Indiana |
| Subdivision Type2: | County |
| Subdivision Name2: | Pike |
| Subdivision Type3: | Township |
| Subdivision Name3: | Patoka |
| Timezone: | Eastern (EST) |
| Utc Offset: | -5 |
| Timezone Dst: | EDT |
| Utc Offset Dst: | -4 |
| Elevation Ft: | 515 |
| Coordinates: | 38.3719°N -87.2408°W |
| Postal Code Type: | ZIP code |
| Postal Code: | 47598 |
| Area Code: | 812 |
| Blank Name: | GNIS feature ID |
| Blank Info: | 430370 |
Ayrshire is an unincorporated community in Patoka Township, Pike County, in the U.S. state of Indiana.
A post office was established at Ayrshire in 1886, and remained in operation until 1917.[1] The community probably took its name from Ayrshire, in Scotland.[2]