Avshalom Caspi Explained

Avshalom Caspi
Birth Date:5 May 1960
Birth Place:Jerusalem, Israel
Nationality:American
Fields:Psychology
Workplaces:Duke University
Institute of Psychiatry, Psychology and Neuroscience at King's College London
Education:University of California at Santa Cruz
Cornell University
Thesis Title:Moving against and moving away: life-course patterns of explosive and withdrawn children
Thesis Url:https://books.google.com/books/about/Moving_against_and_moving_away.html?id=D_JPAAAAYAAJ
Thesis Year:1986
Doctoral Advisors:)-->
Known For:Self-control
Dunedin Multidisciplinary Health and Development Study
Awards:(with Terrie Moffitt) 2016 APA Award for Distinguished Scientific Contributions to Psychology
Spouse:Terrie Moffitt
Partners:)-->

Avshalom Caspi (born May 5, 1960) is an Israeli-American psychologist. He is the Edward M. Arnett Professor of Psychology and Neuroscience in the Trinity College of Arts and Sciences at Duke University and Professor of Personality Development at King's College London's Institute of Psychiatry, Psychology and Neuroscience. His research has focused on mental health and human development, much of which was conducted with his wife and longtime research partner, Terrie Moffitt.[1] He is a co-editor of the Annual Review of Developmental Psychology.

Education

Caspi graduated from the University of California, Santa Cruz with a B.A. in psychology in 1981. He received his M.A. in 1983 and Ph.D. in 1986 in developmental psychology from the Department of Human Development at Cornell University.[2] His doctoral dissertation was titled "Moving Against and Moving Away: Life-course Patterns of Explosive and Withdrawn Children".[3]

Research

Caspi and Moffitt first met when they presented adjacent posters at a 1987 conference in St. Louis, Missouri on "Deviant Pathways from Childhood to Adulthood".[4] [5] He and Moffitt have collaborated on the Dunedin Multidisciplinary Health and Development Study since the 1980s.[4]

Among Caspi's discoveries was that of an association between the 5-HTTLPR polymorphism and clinical depression. This discovery, originally reported in a 2003 study, spurred a wave of subsequent research on the potential genetic roots of various psychiatric conditions.[6] However, a 2017 meta-analysis did not support the original finding,[7] nor did a large analysis with nearly 100% power to detect the original finding.[8] As a result, the general approach of candidate gene or candidate gene by environment interaction research in single small studies is no longer widely accepted.[8] [9] [10] [11]

Another of Caspi's studies concerns the monoamine oxidase A gene variation and the risk of antisocial behavior in the presence of childhood abuse as a study of gene and environment interaction, which was supported by some follow up studies and not by others.[12]

Honors and awards

Caspi is a fellow of the Association for Psychological Science and the British Academy.[1] [13] He and Moffitt were co-recipients of the 2010 Klaus J. Jacobs Research Prize and Best Practice Award from the Jacobs Foundation,[1] and the 2016 APA Award for Distinguished Scientific Contributions to Psychology.[14] In 2013 Caspi was awarded an honorary doctorate from Tilburg University in the Netherlands.[15] In November 2022 Caspi was awarded the Royal Society Te Apārangi's Rutherford Medal, along with the Dunedin Study team leader Richie Poulton and team members Murray Thomson and Moffitt.[16] As of 2024, he became a co-editor of the Annual Review of Developmental Psychology.[17]

Notes and References

  1. News: Husband and Wife Team Trace the Roots of Youth Violence . February 10, 2011 . APS Observer . April 12, 2018.
  2. Web site: Biosketch . Caspi Biosketch 2019 . June 2, 2021.
  3. Web site: Dissertation . MProquest . June 2, 2021. ProQuest .
  4. Two psychologists followed 1000 New Zealanders for decades. Here's what they found about how childhood shapes later life . Starr . Douglas . January 30, 2018 . Science . April 12, 2018.
  5. News: One Shed Fits All: A Modernist Dogtrot Reborn . Green . Penelope . October 3, 2012 . The New York Times . April 12, 2018 .
  6. Study: 'Depression Gene' Doesn't Predict the Blues . Hamilton . Anita . June 17, 2009 . Time . April 12, 2018.
  7. Culverhouse . R. C. . Saccone . N. L. . Horton . A. C. . Ma . Y. . Anstey . K. J. . Banaschewski . T. . Burmeister . M. . Cohen-Woods . S. . Etain . B. . April 4, 2017 . Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression . Molecular Psychiatry . 23 . 1 . 133–142 . 10.1038/mp.2017.44 . 28373689 . 5628077 .
  8. Border . Richard . Johnson . Emma C. . Evans . Luke M. . Smolen . Andrew . Berley . Noah . Sullivan . Patrick F. . Keller . Matthew C. . May 2019 . No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples . American Journal of Psychiatry . 176 . 5 . 376–387 . 10.1176/appi.ajp.2018.18070881 . 6548317 . 30845820.
  9. Duncan LE, Keller MC . A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry . The American Journal of Psychiatry . 168 . 10 . 1041–9 . October 2011 . 21890791 . 3222234 . 10.1176/appi.ajp.2011.11020191 .
  10. Hewitt. John K.. Editorial Policy on Candidate Gene Association and Candidate Gene-by-Environment Interaction Studies of Complex Traits. Behavior Genetics. 42. 1. 2011. 1–2. 10.1007/s10519-011-9504-z. 21928046. 11492871.
  11. Johnson. Emma C.. Border. Richard. Melroy-Greif. Whitney E.. de Leeuw. Christiaan A.. Ehringer. Marissa A.. Keller. Matthew C.. No Evidence That Schizophrenia Candidate Genes Are More Associated With Schizophrenia Than Noncandidate Genes. Biological Psychiatry. 82. 10. 2017. 702–708. 10.1016/j.biopsych.2017.06.033. 28823710. 5643230.
  12. Frazier . Annabelle . Ferreira . Patricia A. . Gonzales . Joseph E. . October 23, 2019 . Born this way? A review of neurobiological and environmental evidence for the etiology of psychopathy . Personality Neuroscience . 2 . e8 . 10.1017/pen.2019.7 . 7219694 . 32435743.
  13. Web site: Professor Avshalom Caspi . British Academy . April 12, 2018.
  14. Web site: APA Award for Distinguished Scientific Contributions . American Psychological Association . April 12, 2018.
  15. Web site: Avshalom Caspi Awards & Honors . Duke Moffitt & Caspi . March 23, 2020.
  16. Web site: The Dunedin Study wins Rutherford Medal and other Research Honours Aotearoa winners celebrated in Ōtepoti Dunedin . November 16, 2022 . Royal Society Te Apārangi.
  17. Web site: CO-EDITORS OF THE ANNUAL REVIEW OF DEVELOPMENTAL PSYCHOLOGY . Annual Reviews . 25 July 2024.