Avizafone Explained

Avizafone^[1] (Pro-Diazepam) is a water-soluble prodrug of the benzodiazepine derivative diazepam. It can be administered intramuscularly.

Avizafone is metabolised by enzymes in the blood to form the active drug diazepam. It is used mainly as an antidote to poisoning with organophosphate nerve agents.^{[2] [3] [4]}

See also

• Alprazolam triazolobenzophenone
• Rilmazafone

Notes and References

1. GB . 1517164 .
2. Karlsson B, Lindgren B, Millquist E, Sandberg M, Sellström A . On the use of diazepam and pro-diazepam (2-benzoyl-4-chloro-N-methyl-N-lysylglycin anilide), as adjunct antidotes in the treatment of organophosphorus intoxication in the guinea-pig . The Journal of Pharmacy and Pharmacology . 42 . 4 . 247–51 . April 1990 . 1974291 . 10.1111/j.2042-7158.1990.tb05401.x . 32369013 .
3. Lallement G, Renault F, Baubichon D, Peoc'h M, Burckhart MF, Galonnier M, Clarençon D, Jourdil N . 6 . Compared efficacy of diazepam or avizafone to prevent soman-induced electroencephalographic disturbances and neuropathology in primates: relationship to plasmatic benzodiazepine pharmacokinetics . Archives of Toxicology . 74 . 8 . 480–6 . October 2000 . 11097386 . 10.1007/s002040000146 . 22292597 .
4. Taysse L, Calvet JH, Buée J, Christin D, Delamanche S, Breton P . Comparative efficacy of diazepam and avizafone against sarin-induced neuropathology and respiratory failure in guinea pigs: influence of atropine dose . Toxicology . 188 . 2–3 . 197–209 . June 2003 . 12767691 . 10.1016/s0300-483x(03)00086-6 .