Aviv Regev Explained

Aviv Regev
Fields:Bioinformatics
Computational Biology
Alma Mater:Tel Aviv University (M.Sc., Ph.D.)
Doctoral Advisor:Eva Jablonka
Ehud Shapiro

Aviv Regev (born 11 July 1971)[1] is a computational biologist and systems biologist and Executive Vice President and Head of Genentech Research and Early Development in Genentech/Roche.[2] She is a core member (on leave) at the Broad Institute of MIT and Harvard and professor (on leave) at the Department of Biology of the Massachusetts Institute of Technology.[3] Regev is a pioneer of single cell genomics and of computational and systems biology of gene regulatory circuits. She founded and leads the Human Cell Atlas project,[4] together with Sarah Teichmann.

Education

Regev studied at the Adi Lautman Interdisciplinary Program for Outstanding Students of Tel Aviv University, where she completed her PhD under the supervision of Eva Jablonka,[5] and Ehud Shapiro.[6]

Career and research

In 2020, Regev became the Head and Executive Vice President of Genentech Research and Early Development, based in South San Francisco, and a member of the extended Corporate Executive Committee of Roche. Previously, she was a Core Institute Member (now on leave), Chair of the Faculty, Founding Director of the Klarman Cell Observatory and co-Director Cell Circuits Program at the Broad Institute of MIT and Harvard. She was also a professor in the Department of Biology at the Massachusetts Institute of Technology (now on leave), as well as an Investigator at the Howard Hughes Medical Institute. Regev's research includes work on gene expression[7] [8] (with Eran Segal and David Botstein), and the use of π-calculus to represent biochemical processes.[9] [10] [11] Regev's team has been a leading pioneer of single-cell genomics experimental and computational methods.[12] In 2014, she pitched the idea of the creation of Human Cell Atlas, a project to describe all cell types in the human body. Regev founded the Human Cell Atlas together with Sarah Teichmann along with collaborators all over the world.

Single Cell Genomics

Regev's lab pioneered the development and application of many of the key experimental and computational advances for single cell and spatial genomics, especially single cell RNA-Seq (scRNA-seq).

Awards and honors

Regev is a fellow of the International Society of Computational Biology (ISCB) (2017),[13] a Helmholtz Fellow (2020),[14] and a fellow of the American Association for Cancer Research (AACR) (2021).[15] She is a member of the US National Academy of Sciences (NAS, elected 2019)[16] and of the US National Academy of Medicine (NAM, elected 2020).[17] She was elected as a foreign member of the Royal Society [18] and as an associate member of the European Molecular Biology Organization in 2024.[19]

Notes and References

  1. Web site: Aviv Regev . broadinstitute.org . https://web.archive.org/web/20171116020135/https://personal.broadinstitute.org/mgarber/cherry813.pdf . 16 November 2017 . 2 December 2021.
  2. https://www.gene.com/about-us/leadership/executive-committee GENENTECH EXECUTIVE COMMITTEE
  3. Web site: Aviv Regev at MIT. biology.mit.edu. 5 November 2017. 6 April 2017. https://web.archive.org/web/20170406021531/https://biology.mit.edu/people/aviv_regev. dead.
  4. Nowogrodzki . Anna . 5 July 2017 . How to build a human cell atlas . . 547 . 7661 . 24–26 . 2017Natur.547...24N . 10.1038/547024a . 28682347 . 211067156. free .
  5. Regev. A.. Lamb. M. J.. Jablonka. E.. 1998. The Role of DNA Methylation in Invertebrates: Developmental Regulation or Genome Defense?. Molecular Biology and Evolution. 15. 7. 880. 10.1093/oxfordjournals.molbev.a025992. 0737-4038. free.
  6. Regev . A. . Shapiro . E. . Cellular abstractions: Cells as computation . Nature . 419 . 6905 . 343 . 2002 . 10.1038/419343a. 12353013 . 3842595 . 2002Natur.419..343R .
  7. Segal . E. . Shapira . M. . Regev . A. . Pe'er . D. . Botstein . D. . Koller . D. . Friedman . N. . 10.1038/ng1165 . Module networks: Identifying regulatory modules and their condition-specific regulators from gene expression data . . 34 . 2 . 166–176 . 2003 . 12740579. 6146032 .
  8. Segal . E. . Friedman . N. . Koller . D. . Regev . A. . A module map showing conditional activity of expression modules in cancer . 2271138. 10.1038/ng1434 . . 36 . 10 . 1090–1098 . 2004 . 15448693 . free .
  9. Regev . A. . Silverman . W. . Shapiro . E. . Representation and simulation of biochemical processes using the pi-calculus process algebra . . 459–470 . 2001 . 11262964. 10.1142/9789814447362_0045 . 978-981-02-4515-3 .
  10. Priami . C. . et al. 10.1016/S0020-0190(01)00214-9 . Application of a stochastic name-passing calculus to representation and simulation of molecular processes . Information Processing Letters . 80 . 25–31 . 2001 .
  11. https://www.news-medical.net/news/20200430/Study-provides-insight-into-regenerative-potential-of-prostate-gland.aspx Study provides insight into regenerative potential of prostate gland
  12. Web site: Aviv Regev. HHMI.org. en. 11 May 2020.
  13. Web site: 2017 ISCB Innovator Award: Aviv Regev . 14 March 2022 . www.iscb.org.
  14. Web site: Event – Helmholtz Zentrum München . 14 March 2022 . www.helmholtz-munich.de.
  15. Web site: Aviv Regev, PhD, FAACR Scientific Awards AACR . 14 March 2022 . American Association for Cancer Research (AACR) . en.
  16. Web site: Aviv Regev . 14 March 2022 . www.nasonline.org.
  17. Web site: 19 October 2020 . National Academy of Medicine Elects 100 New Members . 14 March 2022 . National Academy of Medicine . en-US.
  18. Web site: Outstanding scientists elected as Fellows of the Royal Society .
  19. Web site: EMBO elects 2024 members .
  20. Web site: Aviv Regev: Can AI Help Develop New Medicines .
  21. Web site: Discover the laureates of the 25th L'Oréal-UNESCO For Women in Science International Awards UNESCO . 2 June 2023 . www.unesco.org . en.
  22. Web site: New Members . 30 May 2022 . American Academy of Arts & Sciences . en.
  23. Web site: The Events Calendar .
  24. Web site: Press Release – 2022 HFSP Nakasone Award .
  25. Web site: Foppa . Carolin Arndt . Pioneer in bioinformatics receives ETH Honorary doctorate . 18 March 2022 . bsse.ethz.ch . 22 November 2021 . en.
  26. Web site: Ernst Schering Prize 2021 – Schering Stiftung . 18 March 2022 . en-US.
  27. Web site: James Prize in Science and Technology Integration . 18 March 2022 . www.nasonline.org.
  28. Web site: Snyder . Bill . Regev receives Vanderbilt Prize in Biomedical Science . 18 March 2022 . Vanderbilt University . en.
  29. Web site: Award Ceremony for the 25th Keio Medical Science Prize . 22 December 2020 . keio.ac.jp.
  30. Web site: Announcement of the 25th Keio Medical Science Prize – News – Keio University Medical Science Fund . 18 March 2022 . www.ms-fund.keio.ac.jp.
  31. Web site: Aviv Regev, PhD, FAACR Scientific Awards AACR . 18 March 2022 . American Association for Cancer Research (AACR) . en.
  32. Web site: 2020 FNIH Lurie Prize in Biomedical Sciences Winner Pioneered Innovative Techniques to Shed New Light on Human Health The Foundation for the National Institutes of Health . 18 March 2022 . fnih.org. 18 June 2020 .
  33. Web site: Wimmer . Doris . Aviv Regev . 14 March 2022 . ESHG Conference 2020 . en-GB.
  34. Web site: Kraft Prize Symposium . 14 March 2022 . Massachusetts General Hospital . en.
  35. Web site: Past Recipients . 14 March 2022 . www.faseb.org . en.
  36. Web site: 2019 NAS Election . 30 April 2019 . nasonline.org.
  37. Web site: Weatherall Lectures — MRC Weatherall Institute of Molecular Medicine . 14 March 2022 . www.imm.ox.ac.uk.
  38. Web site: The Harvey Society: Series 113, Lecture 5 . 14 March 2022 . harveysociety.org.
  39. Web site: MIT's Aviv Regev to present annual McCormick Lecture Feb. 1 . 14 March 2022 . News Center . sm.
  40. Web site: 2017 Prize Winners . 12 December 2017 . Memorial Sloan Kettering Cancer Center.
  41. Fogg . Christiana N. . Kovats . Diane E. . Berger . Bonnie . 2017 . 2017 ISCB Innovator Award: Aviv Regev . . 13 . 6 . e1005558 . 2017PLSCB..13E5558F . 10.1371/journal.pcbi.1005558 . 1553-7358 . 5493285 . 28665936 . free .
  42. Web site: February 09, 2017: ISCB Announces 2017 Award Recipients . 10 February 2017 . iscb.org.
  43. Web site: Regev recognized for rigorous integration of experimental and computational approaches . 14 March 2022 . www.asbmb.org . en.
  44. https://www.bwfund.org/focus-bwf-research-0610 Dynamic single-cell imaging of direct reprogramming reveals an early specifying event – Nature Biotechnology: Aviv Regev, Ph.D. – Career Awards at the Scientific Interface; Ab initio reconstruction of cell type–specific transcriptomes in mouse reveals the conserved multi-exonic structure of lincRNAs – Nature Biotechnology: Aviv Regev, Ph.D. – Career Awards at the Scientific Interface
  45. Web site: Three faculty win '08 NIH Pioneer Awards . 6 March 2022 . MIT News Massachusetts Institute of Technology . 22 September 2008 . en.
  46. Web site: 2008 NIH Director's Pioneer Award . 30 July 2019 . 30 July 2019 . https://web.archive.org/web/20190730080525/https://www.bwfund.org/awards-and-accolades-summer-2008 . dead .

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