| Official Name: | Santa Clara de Avedillo |
| Subdivision Name3: | Santa Clara de Avedillo |
| Area Total Km2: | 16 |
| Population Density Km2: | auto |
| Utc Offset: | +1 |
| Utc Offset Dst: | +2 |
Santa Clara de Avedillo is a municipality located in the province of Zamora, Castile and León, Spain. According to the 2004 census (INE), the municipality has a population of 240 inhabitants.