| Country: | ESP |
| Type: | Autovia |
| Route: | A-50 |
| Alternate Name: | Autovía Ávila - Salamanca |
| Length Km: | 100 |
| Length Round: | 1 |
| Terminus A: | Ávila |
| Terminus B: | Salamanca |
The Autovía A-50 (also known as Autovía Ávila - Salamanca and Autovía de la Cultura) is an autovía in the community of Castile and León, Spain. It starts at the Autovía A-51 at Ávila and ends on the southern outskirts of Salamanca, close to the Autovía A-62 and the Autovía A-66, while running parallel to the N-501 road. It was built between 2006 and 2009.