Autologous stem-cell transplantation explained

Autologous stem-cell transplantation (also called autogenous, autogenic, or autogenic stem-cell transplantation and abbreviated auto-SCT) is the autologous transplantation of stem cells^{[1] [2]} —that is, transplantation in which stem cells (undifferentiated cells from which other cell types develop) are removed from a person, stored, and later given back to that same person.^{[3] [4] [5]}

Although it is most frequently performed with hematopoietic stem cells (precursors of blood-forming cells) in hematopoietic stem cell transplantation, cardiac cells have also been used successfully to repair damage caused by heart attacks.^[6]

Autologous stem-cell transplantation is distinguished from allogenic stem cell transplantation where the donor and the recipient of the stem cells are different people.

It can be also used as an Assisted reproductive technology to improve the reproductive outcomes. In a first step the bone marrow derived stem cells are mobilized. After that they will be isolated from the peripheral blood by apheresis. The treated stem cells will then be infused into the ovarian artery through catheterism.

See also

• Autologous hematopoietic stem-cell transplantation
• Stem-cell therapy

References

9. Herraiz et al., (2018). Autologous stem cell ovarian transplantation to increase reproductive potential in patients who are poor responders. Fertil Steril, 110(3), 496-505.

External links

• Autologous stem-cell transplantation entry in the public domain NCI Dictionary of Cancer Terms
• ScienceDaily Report University of Louisville. "Two years out, patients receiving stem cell therapy show sustained heart function improvement, study suggests." ScienceDaily, 6 Nov. 2012. Web. 6 Nov. 2012.

Notes and References

1. News: What Are Stem Cells?. 2017-02-12. en-US.
2. Al-Daccak . R. . Charron . D. . 2015-07-23 . Allogenic benefit in stem cell therapy: cardiac repair and regeneration . Tissue Antigens . 86 . 3 . 155–162 . 10.1111/tan.12614 . 0001-2815.
3. Mahla RS. Stem cells application in regenerative medicine and disease threpeutics . International Journal of Cell Biology . 2016 . 7 . 19 . 2016 . 27516776 . 10.1155/2016/6940283 . 4969512 . free .
4. Web site: Autologous (Self) Transplants. The Leukaemia Foundation. The Leukaemia Foundation. 27 September 2017. 17 March 2018. https://web.archive.org/web/20180317130658/http://leukaemia.org.au/treatments/stem-cell-transplants/autologous-self-transplants. dead.
5. 2020-01-19 . Acknowledgement to Reviewers of Cells in 2019 . Cells . 9 . 1 . 251 . 10.3390/cells9010251 . 2073-4409. free . 3980745 .
6. Stamm. Christof. Westphal. Bernd. Kleine. Hans-Dieter. Petzsch. Michael. Kittner. Christian. Klinge. Heiko. Schümichen. Carl. Nienaber. Christoph A. Freund. Mathias. 2003-01-04. Autologous bone-marrow stem-cell transplantation for myocardial regeneration. The Lancet. 361. 9351. 45–46. 10.1016/S0140-6736(03)12110-1. 12517467. 23858666.