Atrolysin E Explained

Atrolysin E
Ec Number:3.4.24.44
Cas Number:172306-51-3

Atrolysin E (Crotalus atrox metalloendopeptidase e, hemorrhagic toxin e) is an enzyme.[1] [2] [3] This enzyme catalyses the following chemical reaction

Cleavage of Asn3-Gln, Ser9-His and Ala14-Leu bonds in insulin B chain and Tyr14-Gln and Thr8-Ser in A chain. Cleaves type IV collagen at Ala73-Gln in alpha1(IV) and at Gly7-Leu in alpha2(IV)

This endopeptidase is present in the venom of the western diamondback rattlesnake (Crotalus atrox).

Notes and References

  1. Bjarnason JB, Tu AT . Hemorrhagic toxins from Western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e . Biochemistry . 17 . 16 . 3395–404 . August 1978 . 210790 . 10.1021/bi00609a033 .
  2. Bjarnason JB, Fox JW . Proteolytic specificity and cobalt exchange of hemorrhagic toxin e, a zinc protease isolated from the venom of the western diamondback rattlesnake (Crotalus atrox) . Biochemistry . 22 . 16 . 3770–8 . August 1983 . 6351911 . 10.1021/bi00285a009 .
  3. Baramova EN, Shannon JD, Bjarnason JB, Fox JW . Identification of the cleavage sites by a hemorrhagic metalloproteinase in type IV collagen . Matrix . 10 . 2 . 91–7 . May 1990 . 2374521 . 10.1016/s0934-8832(11)80175-7 .

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