Atrolysin C Explained

Atrolysin C
Ec Number:3.4.24.42
Cas Number:158886-17-0

Atrolysin C (Crotalus atrox metalloendopeptidase c, hemorrhagic toxin c and d) is an enzyme.[1] [2] [3] [4] [5] [6] This enzyme catalyses the following chemical reaction

Cleavage of His5-Leu, His10-Leu, Ala14-Leu, Tyr16-Leu and Gly23-Phe bonds in B chain of insulin. With small molecule substrates prefers hydrophobic residue at P2' and small residue such as Ala, Gly at P1

This endopeptidase is present in the venom of the western diamondback rattlesnake (Crotalus atrox).

Notes and References

  1. Bjarnason JB, Tu AT . Hemorrhagic toxins from Western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e . Biochemistry . 17 . 16 . 3395–404 . August 1978 . 210790 . 10.1021/bi00609a033 .
  2. Fox JW, Campbell R, Beggerly L, Bjarnason JB . Substrate specificities and inhibition of two hemorrhagic zinc proteases Ht-c and Ht-d from Crotalus atrox venom . European Journal of Biochemistry . 156 . 1 . 65–72 . April 1986 . 3514216 . 10.1111/j.1432-1033.1986.tb09549.x . free .
  3. Bjarnason JB, Fox JW . Characterization of two hemorrhagic zinc proteinases, toxin c and toxin d, from western diamondback rattlesnake (Crotalus atrox) venom . Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology . 911 . 3 . 356–63 . February 1987 . 3101740 . 10.1016/0167-4838(87)90077-x .
  4. Mori N, Nikai T, Sugihara H, Tu AT . Biochemical characterization of hemorrhagic toxins with fibrinogenase activity isolated from Crotalus ruber ruber venom . Archives of Biochemistry and Biophysics . 253 . 1 . 108–21 . February 1987 . 2949699 . 10.1016/0003-9861(87)90643-6 .
  5. Shannon JD, Baramova EN, Bjarnason JB, Fox JW . Amino acid sequence of a Crotalus atrox venom metalloproteinase which cleaves type IV collagen and gelatin . The Journal of Biological Chemistry . 264 . 20 . 11575–83 . July 1989 . 2745407 .
  6. Takeya H, Onikura A, Nikai T, Sugihara H, Iwanaga S . Primary structure of a hemorrhagic metalloproteinase, HT-2, isolated from the venom of Crotalus ruber ruber . Journal of Biochemistry . 108 . 5 . 711–9 . November 1990 . 10.1093/oxfordjournals.jbchem.a123270 . 2081731 .

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