The men's 4 × 100 metres relay event at the 2003 All-Africa Games was held on October 14–15.
| width=200 valign=top | Christian Nsiah Eric Nkansah Aziz Zakari Leonard Myles-Mills | width=200 valign=top | Aaron Egbele Tamunosiki Atorudibo Musa Deji Deji Aliu | width=200 valign=top | Oumar Loum Félou Doudou Sow Gora Diop Abdou Demba Lam |
Qualification: First 3 teams of each heat (Q) plus the next 2 fastest (q) qualified for the final.
| Rank | Heat | Nation | Athletes | Time | Notes | |
|---|---|---|---|---|---|---|
| 1 | 2 | 39.23 | Q | |||
| 2 | 1 | 39.99 | Q | |||
| 3 | 1 | 40.01 | Q | |||
| 4 | 2 | 40.41 | Q | |||
| 5 | 1 | 40.52 | Q | |||
| 6 | 2 | 40.79 | Q | |||
| 7 | 1 | 40.80 | q | |||
| 8 | 1 | 40.81 | q | |||
| 9 | 2 | 41.60 | ||||
| 10 | 2 | 41.63 | ||||
| 2 |
| Rank | Nation | Athletes | Time | Notes | |
|---|---|---|---|---|---|
| 38.63 | |||||
| 38.70 | |||||
| 38.79 | |||||
| 4 | 39.94 | ||||
| 5 | 40.06 | ||||
| 6 | 40.49 | ||||
| 7 | 40.81 | ||||
| 8 | 40.87 |